scholarly journals The Usefulness of Bone Turnover in Predicting the Response to Transdermal Estrogen Therapy in Postmenopausal Osteoporosis

1997 ◽  
Vol 12 (4) ◽  
pp. 624-631 ◽  
Author(s):  
S. Gonnelli ◽  
C. Cepollaro ◽  
C. Pondrelli ◽  
S. Martini ◽  
R. Monaco ◽  
...  
1996 ◽  
Vol 6 (S1) ◽  
pp. 223-223
Author(s):  
S. Gonnelli ◽  
D. Agnusdei ◽  
C. Cepollaro ◽  
R. Palmieri ◽  
P. Pondrelli ◽  
...  

2013 ◽  
Vol 26 (2) ◽  
pp. 71-79 ◽  
Author(s):  
Lisa Kenigsberg ◽  
Sadana Balachandar ◽  
Kris Prasad ◽  
Bina Shah

2014 ◽  
Vol 20 (3) ◽  
pp. 111 ◽  
Author(s):  
Hyo Jeong Kim ◽  
Yoon Kyung Oh ◽  
Ji Soo Lee ◽  
Dong-Yun Lee ◽  
DooSeok Choi ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xiao-Juan Xu ◽  
Lin Shen ◽  
Yan-Ping Yang ◽  
Rui Zhu ◽  
Bo Shuai ◽  
...  

Objective. To demonstrate the role of Wnt/β-catenin canonical pathway in postmenopausal osteoporosis by evaluating serumβ-catenin levels in patients with postmenopausal osteoporosis and analyzing their possible relationship with serum OPG, RANKL, the ratio of RANKL/OPG, sclerostin, and bone turnover markers.Methods. 480 patients with postmenopausal osteoporosis and 170 healthy postmenopausal women were enrolled in the study. Serumβ-catenin, OPG, RANKL, and sclerostin levels were measured by enzyme-linked immunosorbent assay. Bone status was assessed by measuring bone mineral density and bone turnover markers. Estradiol levels were also detected.Results. Serumβ-catenin levels were lower in postmenopausal osteoporotic women compared to nonosteoporotic postmenopausal women (26.26±14.81versus39.33±5.47 pg/mL,P<0.001). Serumβ-catenin was positively correlated with osteoprotegerin (r=0.232,P<0.001) and negatively correlated with the ratio of RANKL/OPG, body mass index, and sclerostin (r=-0.128,P=0.005;r=-0.117,P=0.010;r=-0.400,P<0.001, resp.) in patients with postmenopausal osteoporosis.Conclusion. The results indicate that lower serumβ-catenin and concomitantly higher ratio of RANKL/OPG may be involved in the pathogenesis of postmenopausal osteoporosis. Functional communication between RANKL/RANK/OPG system and Wnt pathways plays an important role in postmenopausal osteoporosis.


Bone ◽  
1995 ◽  
Vol 16 (6) ◽  
pp. 683
Author(s):  
M. France ◽  
S. Bowles ◽  
A. Davis ◽  
M.T.A. Rehman ◽  
P.L. Selby ◽  
...  

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