scholarly journals Skeletal Effects of Parathyroid Hormone Infusion in Ovariectomized Rats With or Without Estrogen Repletion

2010 ◽  
Vol 15 (4) ◽  
pp. 740-746 ◽  
Author(s):  
V. Shen ◽  
R. Birchman ◽  
D.-D. Wu ◽  
R. Lindsay
Keyword(s):  
Parathyroid Hormone ◽  
Ovariectomized Rats ◽  
Skeletal Effects

Skeletal effects of calcitonin treatment and withdrawal in ovariectomized rats

1996 ◽  
Vol 58 (4) ◽  
pp. 263-267 ◽  
Author(s):  
Y. Shen ◽  
M. Li ◽  
T. J. Wronski
Keyword(s):  
Ovariectomized Rats ◽  
Calcitonin Treatment ◽  
Skeletal Effects

scholarly journals Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Ying-Ju Chen ◽  
Shun-Ping Wang ◽  
Fu-Chou Cheng ◽  
Pei-Yu Hsu ◽  
Yu-Fen Li ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Femoral Head ◽  
Bone Microarchitecture ◽  
Ovariectomized Rats

Estrogens and progestogens conserve bone in rats deficient in calcitonin and parathyroid hormone

1989 ◽  
Vol 257 (6) ◽  
pp. E903-E908
Author(s):  
A. Goulding ◽  
E. Gold
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Ovariectomized Rats ◽  
Lower Plasma ◽  
Urinary Hydroxyproline ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Thyroxine Replacement ◽  
Total Body ◽  
D Values

To examine the abilities of estrogens and progestogens to slow bone resorption and conserve bone in ovariectomized rats deficient in calcitonin (CT) or parathyroid hormone (PTH), nine groups of animals with 45Ca-labeled bones were studied for 12 wk. Rats were thyroidectomized (TX), parathyroidectomized (PTX), or given sham neck operations (Sham) and treated orally with either estrogen, 300 micrograms 17 beta-estradiol.kg body wt-1.wk-1; progestogen, 500 micrograms norethisterone acetate.kg body wt-1.wk-1; or placebo (Plac). The TX rats had parathyroid autografts and thyroxine replacement. In all surgical groups, estradiol (E2) and norethindrone (Nor) slowed urinary 45Ca excretion and conserved bone (P less than 0.001). However E2 lowered urinary hydroxyproline more than Nor. Total body Ca values (mg +/- SD) were Sham + Plac, 3,079 +/- 201; Sham + E2, 3,886 +/- 335; Sham + Nor, 3,567 +/- 459; TX + Plac, 3,123 +/- 159; TX + E2, 3,869 +/- 235; TX + Nor, 3,540 +/- 422; PTX + Sham, 3,067 +/- 249; PTX + E2, 3,775 +/- 414; PTX + Nor, 3,635 +/- 467. Importantly, E2 and Nor conserved bone as effectively in TX and PTX groups as in Sham rats, although the PTX rats had slower bone resorption and lower plasma 1,25-dihydroxyvitamin D values (P less than 0.001) than groups with intact parathyroids. We conclude that the effects of estrogens and progestogens to slow bone resorption and conserve bone are independent of CT and PTH. These findings appear relevant to the pathogenesis and treatment of postmenopausal osteoporosis.

scholarly journals Restoring Effect of Human Parathyroid Hormone (1-34) on Trabecular Connectivity in Ovariectomized Rats.

2001 ◽  
Vol 194 (4) ◽  
pp. 213-221 ◽  
Author(s):  
Tsunehisa Tsuchida ◽  
Naohisa Miyakoshi ◽  
Takuya Kudo ◽  
Yasuki Tamura ◽  
Yuji Kasukawa ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Ovariectomized Rats ◽  
Human Parathyroid Hormone ◽  
Trabecular Connectivity
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