scholarly journals Activity of Clinically Relevant Antimalarial Drugs on Plasmodium falciparum Mature Gametocytes in an ATP Bioluminescence “Transmission Blocking” Assay

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35019 ◽  
Author(s):  
Joël Lelièvre ◽  
Maria Jesus Almela ◽  
Sonia Lozano ◽  
Celia Miguel ◽  
Virginia Franco ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Drugs ◽  
Transmission Blocking ◽  
Atp Bioluminescence ◽  
Blocking Assay

scholarly journals Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence “transmission blocking”assay

2012 ◽  
Vol 11 (Suppl 1) ◽  
pp. P7 ◽  
Author(s):  
Joël Lelièvre ◽  
Maria Almela ◽  
Sonia Lozano ◽  
Celia Miguel ◽  
Virginia Franco ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Drugs ◽  
Transmission Blocking ◽  
Atp Bioluminescence ◽  
Blocking Assay

scholarly journals Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine

2016 ◽  
Vol 60 (5) ◽  
pp. 3145-3147 ◽  
Author(s):  
Julia Penna-Coutinho ◽  
Maria Jesús Almela ◽  
Celia Miguel-Blanco ◽  
Esperanza Herreros ◽  
Paula M. Sá ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Drugs ◽  
Dual Roles ◽  
Hybrid Compound ◽  
Transmission Blocking ◽  
Content Type

ABSTRACTMost antimalarial drugs target asexual parasites without reducing gametocyte formation or development. Drugs with dual roles, i.e., those that can target both asexual parasites and gametocytes, would improve the control of malaria. In the current study, MEFAS, a hybrid drug derived from mefloquine and artesunate that has been shown to be an active blood schizonticidal drug, was assessed to determine its ability to block the infectivity ofPlasmodium falciparumgametocytes. MEFAS was 280 and 15 times more effective than mefloquine alone and artesunate alone, respectively.

scholarly journals A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79538 ◽  
Author(s):  
R. Mark Jones ◽  
Jessica A. Chichester ◽  
Vadim Mett ◽  
Jennifer Jaje ◽  
Stephen Tottey ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Transmission Blocking ◽  
Malaria Vaccine Candidate ◽  
Blocking Antibodies

scholarly journals Immunoprecipitation of [3H]Dihydroartemisinin Translationally Controlled Tumor Protein (TCTP) Adducts from Plasmodium falciparum-Infected Erythrocytes by Using Anti-TCTP Antibodies

2001 ◽  
Vol 45 (8) ◽  
pp. 2397-2399 ◽  
Author(s):  
Jamaree Bhisutthibhan ◽  
Steven R. Meshnick
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Drugs ◽  
Translationally Controlled Tumor Protein

ABSTRACT Artemisinin and its derivatives are endoperoxide-containing antimalarial drugs that appear to form adducts in situ with thePlasmodium falciparum translationally controlled tumor protein (TCTP) homolog. Immunoprecipitation with antibody to recombinant TCTP suggests that adducts may form with both monomeric and dimeric TCTP.

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