scholarly journals Nicorandil Prevents Right Ventricular Remodeling by Inhibiting Apoptosis and Lowering Pressure Overload in Rats with Pulmonary Arterial Hypertension

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44485 ◽  
Author(s):  
Xiang-Rong Zuo ◽  
Qiang Wang ◽  
Quan Cao ◽  
Yan-Zhe Yu ◽  
Hui Wang ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Right Ventricular ◽  
Ventricular Remodeling ◽  
Pressure Overload ◽  
Pulmonary Arterial ◽  
Right Ventricular Remodeling

scholarly journals Right Ventricular Remodeling in Idiopathic and Scleroderma-Associated Pulmonary Arterial Hypertension: Two Distinct Phenotypes

2015 ◽  
Vol 5 (2) ◽  
pp. 327-334 ◽  
Author(s):  
Benjamin W. Kelemen ◽  
Stephen C. Mathai ◽  
Ryan J. Tedford ◽  
Rachel L. Damico ◽  
Cecilia Corona-Villalobos ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Right Ventricular ◽  
Ventricular Remodeling ◽  
Pulmonary Arterial ◽  
Right Ventricular Remodeling

Pulmonary artery banding is a relevant model to study the right ventricular remodeling and dysfunction that occurs in pulmonary arterial hypertension

2020 ◽  
Vol 129 (2) ◽  
pp. 238-246 ◽  
Author(s):  
Yohei Akazawa ◽  
Kenichi Okumura ◽  
Ryo Ishii ◽  
Cameron Slorach ◽  
Wei Hui ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Pulmonary Artery ◽  
Arterial Hypertension ◽  
Right Ventricular ◽  
Ventricular Remodeling ◽  
Pressure Overload ◽  
Pulmonary Artery Banding ◽  
Vascular Effects ◽  
Pulmonary Arterial ◽  
The Right

Although animal models of pulmonary arterial hypertension and pressure loading are important to study right ventricular (RV) pathophysiology, pulmonary arterial hypertension models cannot interrogate RV responses independent of pulmonary vascular effects. Comparing three commonly used rat models under similar elevated RV pressure, we found that all models resulted in comparable maladaptive RV remodeling and dysfunction. Thus, these findings suggest that the pulmonary artery banding model can be used to investigate mechanisms of RV dysfunction in RV pressure overload and the effect of potential therapies.

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