Positional and Curvature Difference of Lamina Cribrosa According to the Baseline Intraocular Pressure in Primary Open-Angle Glaucoma: A Swept-Source Optical Coherence Tomography (SS-OCT) Study

Background/Aim. Glaucoma is a progressive optic neuropathy characterized by damage of the retinal ganglion cells and their axons and glial cells. The aim of this study was to evaluate the differences and connections between changes in the visual field and the thickness of the peripapillary retinal nerve fiber layer (RNFL), using optical coherence tomography (OCT) in patients with primary open-angle glaucoma with normal and elevated intraocular pressure (IOP). Methods. This prospective study included 38 patients (38 eyes) with primary open-angle glaucoma with normal intraocular pressure (NTG) and 50 patients (50 eyes) with primary open-angle glaucoma with elevated intraocular pressure (HTG), paired by the same degree of structural glaucomatous changes in the optic nerve head and by age. OCT protocols ?fast RNFL thickness? and ?fast optic disc? were used for testing. The patients? age, gender, best corrected visual acuity (BCVA), IOP, stereometric and functional parameters were compared. Results. The average age of the examined population was 65.49 ? 9.36 (range 44-83) years. There was no statistically significant difference by age and by gender between the two study groups (p = 0.795 and p = 0.807, respectively). BCVA was higher in patients with NTG but there was no statistically significant difference compared to HTG patients (p = 0.160). IOP was statistically significantly higher in patients with HTG compared to NTG patients (17.40 ? 2.77 mmHg vs 14.95 ? 3.01 mmHg, p = 0.009). The cup/disc (C/D) (p = 0.258), mean deviation (MD) (p = 0.477), corrected patern standard deviation (CPSD) (p = 0.943), disk area (p = 0.515), rim area (p = 0.294), rim volume (p = 0.118), C/D area R (p = 0.103), RNFL Average (p = 0.632), RNFL Superior (p = 0.283) and RNFL Inferior (p = 0.488) were not statistically significantly different between the groups. Conclusion. OCT measurements of the RNFL thickness provide clinically significant information in monitoring of glaucomatous changes. There are no differences in the patterns of RNFL defects per sectors and quadrants between NTG and HTG, measured by OCT.

Download Full-text

Structural Changes in the Optic Disc and Macula Detected by Swept-Source Optical Coherence Tomography After Surgical Intraocular Pressure Reduction in Patients with Open-Angle Glaucoma

Clinical Ophthalmology ◽

10.2147/opth.s317190 ◽

2021 ◽

Vol Volume 15 ◽

pp. 3017-3026

Author(s):

Roberto Vessani ◽

Thalyta Frota ◽

Gabriella Shigetomi ◽

Priscila Correa ◽

Eduardo B Mariottoni ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Pressure ◽

Optic Disc ◽

Structural Changes ◽

Open Angle Glaucoma ◽

Optical Coherence ◽

Pressure Reduction ◽

Open Angle ◽

Swept Source ◽

Intraocular Pressure Reduction

Download Full-text

The Role of Optical Coherence Tomography Angiography in Moderate and Advanced Primary Open-Angle Glaucoma

10.21203/rs.3.rs-710633/v1 ◽

2021 ◽

Author(s):

Yadollah Eslami ◽

Sepideh Ghods ◽

Massood Mohammadi ◽

Mona Safizadeh ◽

Ghasem Fakhraie ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Mean Deviation ◽

Optical Coherence ◽

Open Angle ◽

The Mean ◽

Inferior Quadrant

Abstract Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG.Methods: In this cross-sectional study 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation between structure and vasculature and the mean deviation (MD) of the VFs was evaluated by a partial correlation coefficient. The area under the receiver operating characteristic curve (AUC) was applied for assessing the power of variables for discrimination moderate from advanced POAG.Results: Superior cpRNFL, superior GCC, whole image vessel density (wiVD) of the ONH area, and vessel density in inferior quadrant of perifovea had the strongest correlation with the mean deviation (MD) of the VF 24-2 (r= .351, .558, .649 and .397; p< .05). The greatest AUCs belonged to inferior cpRNFL (.789), superior GCC (.818), vessel density of the inferior hemifield of ONH area (.886), and vessel density in inferior quadrant of perifovea (.833) without statistically significant difference in pairwise comparison.Conclusion: Vasculature has a stronger correlation than the structure with MD in moderate and advanced POAG and is as accurate as structure in discrimination moderate from advanced POAG.

Download Full-text