scholarly journals Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?

2018 ◽  
Vol 14 (11) ◽  
pp. e1007351 ◽  
Author(s):  
André Schneider
Keyword(s):  
Protein Import ◽  
Mitochondrial Protein ◽  
Mitochondrial Protein Import ◽  
Variations On A Theme

scholarly journals Structural Basis of Presequence Recognition by the Mitochondrial Protein Import Receptor Tom20

Cell ◽  
2000 ◽  
Vol 100 (5) ◽  
pp. 551-560 ◽  
Author(s):  
Yoshito Abe ◽  
Toshihiro Shodai ◽  
Takanori Muto ◽  
Katsuyoshi Mihara ◽  
Hisayoshi Torii ◽  
...  
Keyword(s):  
Protein Import ◽  
Mitochondrial Protein ◽  
Structural Basis ◽  
Mitochondrial Protein Import ◽  
Import Receptor

scholarly journals MitoCPR: a novel protective mechanism in response to mitochondrial protein import stress

2018 ◽  
Vol 50 (10) ◽  
pp. 1072-1074 ◽  
Author(s):  
Mingzhu Tang ◽  
Xuling Luo ◽  
Zhen Huang ◽  
Linxi Chen
Keyword(s):  
Protein Import ◽  
Mitochondrial Protein ◽  
Protective Mechanism ◽  
Mitochondrial Protein Import

Mutant Preproteins Clog Global Mitochondrial Protein Import to Cause Degenerative Disease

2021 ◽  
Author(s):  
Liam P. Coyne ◽  
Xiaowen Wang ◽  
Jiyao Song ◽  
Ebbing de Jong ◽  
Karin Schneider ◽  
...  
Keyword(s):  
Protein Import ◽  
Mitochondrial Protein ◽  
Degenerative Disease ◽  
Mitochondrial Protein Import

Dynamic organization of the mitochondrial protein import machinery

2016 ◽  
Vol 397 (11) ◽  
pp. 1097-1114 ◽  
Author(s):  
Sebastian P. Straub ◽  
Sebastian B. Stiller ◽  
Nils Wiedemann ◽  
Nikolaus Pfanner
Keyword(s):  
Mitochondrial Membrane ◽  
Protein Import ◽  
Mitochondrial Protein ◽  
Membrane Dynamics ◽  
Intermembrane Space ◽  
Mitochondrial Protein Import ◽  
Precursor Proteins ◽  
Dynamic Cooperation

Abstract Mitochondria contain elaborate machineries for the import of precursor proteins from the cytosol. The translocase of the outer mitochondrial membrane (TOM) performs the initial import of precursor proteins and transfers the precursors to downstream translocases, including the presequence translocase and the carrier translocase of the inner membrane, the mitochondrial import and assembly machinery of the intermembrane space, and the sorting and assembly machinery of the outer membrane. Although the protein translocases can function as separate entities in vitro, recent studies revealed a close and dynamic cooperation of the protein import machineries to facilitate efficient transfer of precursor proteins in vivo. In addition, protein translocases were found to transiently interact with distinct machineries that function in the respiratory chain or in the maintenance of mitochondrial membrane architecture. Mitochondrial protein import is embedded in a regulatory network that ensures protein biogenesis, membrane dynamics, bioenergetic activity and quality control.

Mitochondrial protein-import machinery: correlating structure with function

2007 ◽  
Vol 17 (9) ◽  
pp. 456-464 ◽  
Author(s):  
Michael J. Baker ◽  
Ann E. Frazier ◽  
Jacqueline M. Gulbis ◽  
Michael T. Ryan
Keyword(s):  
Protein Import ◽  
Mitochondrial Protein ◽  
Mitochondrial Protein Import
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