scholarly journals Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons

2020 ◽  
Vol 16 (2) ◽  
pp. e1008380 ◽  
Author(s):  
Pavithra Aravamudhan ◽  
Krishnan Raghunathan ◽  
Jennifer Konopka-Anstadt ◽  
Amrita Pathak ◽  
Danica M. Sutherland ◽  
...  
Keyword(s):  
Axonal Transport ◽  
Fast Axonal Transport

scholarly journals Kinesin Mutations Cause Motor Neuron Disease Phenotypes by Disrupting Fast Axonal Transport in Drosophila

Genetics ◽  
1996 ◽  
Vol 144 (3) ◽  
pp. 1075-1085 ◽  
Author(s):  
Daryl D Hurd ◽  
William M Saxton
Keyword(s):  
Motor Neuron ◽  
Axonal Transport ◽  
Action Potentials ◽  
Light And Electron Microscopy ◽  
Synaptic Membrane ◽  
Slow Axonal Transport ◽  
Fast Axonal Transport ◽  
Motor Neuron Diseases ◽  
Transmitter Secretion ◽  
Axon Terminals

Abstract Previous work has shown that mutation of the gene that encodes the microtubule motor subunit kinesin heavy chain (Khc) in Drosophila inhibits neuronal sodium channel activity, action potentials and neurotransmitter secretion. These physiological defects cause progressive distal paralysis in larvae. To identify the cellular defects that cause these phenotypes, larval nerves were studied by light and electron microscopy. The axons of Khc mutants develop dramatic focal swellings along their lengths. The swellings are packed with fast axonal transport cargoes including vesicles, synaptic membrane proteins, mitochondria and prelysosomal organelles, but not with slow axonal transport cargoes such as cytoskeletal elements. Khc mutations also impair the development of larval motor axon terminals, causing dystrophic morphology and marked reductions in synaptic bouton numbers. These observations suggest that as the concentration of maternally provided wild-type KHC decreases, axonal organelles transported by kinesin periodically stall. This causes organelle jams that disrupt retrograde as well as anterograde fast axonal transport, leading to defective action potentials, dystrophic terminals, reduced transmitter secretion and progressive distal paralysis. These phenotypes parallel the pathologies of some vertebrate motor neuron diseases, including some forms of amyotrophic lateral sclerosis (ALS), and suggest that impaired fast axonal transport is a key element in those diseases.

Continuation of fast axonal transport in regenerating axons in vitro

1979 ◽  
Vol 57 (11) ◽  
pp. 1251-1255
Author(s):  
M. A. Bisby ◽  
C. E. Hilton
Keyword(s):  
Sciatic Nerve ◽  
Vagus Nerve ◽  
Axonal Transport ◽  
Nerve Injury ◽  
Axon Regeneration ◽  
Free Medium ◽  
Fast Axonal Transport ◽  
Sensory Axons

A previous study by McLean and co-workers reported that regenerating axons of the rabbit vagus nerve were unable to sustain axonal transport in vitro for several months after nerve injury. In contrast, we found that sensory axons of the rat sciatic nerve were able to transport 3H-labeled protein into their regenerating portions distal to the site of injury within a week after injury when placed in vitro. Transport in vitro was not significantly less than transport in axons maintained in vivo for the same period. Transport occurred in the medium that was used by the McLean group, but was significantly reduced in calcium-free medium. When axon regeneration was delared, only small amounts of activity were present in the nerve distal to the site of injury, showing that labeled protein normally present in that part of the nerve was associated with axons and was not a result of local precursor uptake by nonneural elements in the sciatic nerve. We were not able to explain the failure of McLean and co-workers to demonstrate transport in vitro in regenerating vagus nerve, but we conclude that there is no general peculiarity of growing axons that makes them unable to sustain transport in vitro.

FAST AXONAL TRANSPORT THROUGH GIANT AXONAL SWELLINGS IN HEXACARBON NEUROPATHY

1977 ◽  
Vol 36 (3) ◽  
pp. 602 ◽  
Author(s):  
J. W. Griffin ◽  
D. L. Price ◽  
P. S. Spencer
Keyword(s):  
Axonal Transport ◽  
Fast Axonal Transport ◽  
Axonal Swellings

Organelles in fast axonal transport

1992 ◽  
Vol 6 (2-3) ◽  
pp. 157-177 ◽  
Author(s):  
Annica B. Dahlström ◽  
Andrew J. Czernik ◽  
Jia-Yi Li
Keyword(s):  
Axonal Transport ◽  
Fast Axonal Transport

Rapid and precise down regulation of fast axonal transport of transmitter in an identified neuron

Science ◽  
1982 ◽  
Vol 218 (4575) ◽  
pp. 913-916 ◽  
Author(s):  
J. Aletta ◽  
D. Goldberg
Keyword(s):  
Axonal Transport ◽  
Fast Axonal Transport ◽  
Down Regulation ◽  
Identified Neuron

P3-258 Molecular motors implicated in the fast axonal transport of tau

2004 ◽  
Vol 25 ◽  
pp. S428
Author(s):  
Wendy J. Noble ◽  
Michelle A. Utton ◽  
Brian H. Anderton ◽  
Diane P. Hanger
Keyword(s):  
Axonal Transport ◽  
Molecular Motors ◽  
Fast Axonal Transport
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