Nasal CPAP Continues to Improve Sleep-Disordered Breathing and Daytime Oxygenation over Long-term Follow-up of Occlusive Sleep Apnea Syndrome

Background: The purpose of this study was to evaluate long-term subjective outcomes of barbed reposition pharyngoplasty for obstructive sleep apnea syndrome (OSAS) treatment using a specific questionnaire, the Palate Postoperative Problem Score (PPOPS). Methods: 140 patients who underwent barbed reposition pharyngoplasty (BRP) surgery in the Morgagni Pierantoni Hospital of Forlì, Italy were enrolled in the study. Postoperative outcomes were evaluated in a short- and long-term follow-up using the PPOPS questionnaire. The average period of follow-up was 26 months. All patients received the PPOPS questionnaire by telephone in a period between April and August 2019. Results: 51% of patients complained of swallowing problems after surgery. In 91% of cases, the problem cleared up spontaneously. At the time of the interview, only 9% of patients had a residual swallowing difficult. At the time of PPOPS evaluation, rhinolalia was observed in 8% of patients, whereas nose regurgitation was present in 2% of patients. In 20% of patients, the foreign body sensation was present during follow-up. The value of apnea–hypopnea index (AHI) reduced from the preoperative value of 31.5 to the postoperative value of 11.4. Conclusions: BRP surgery proved to be an effective technique, appreciated by the majority of patients. Use of the PPOPS questionnaire has demonstrated that the BRP technique seems to ensure efficacy and lower morbidity, with few complications after surgery.

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G301 Prevalence of sleep disordered breathing and sleep apnea syndrome in healthy workers(Oral Presentation,Occupational Health in the Age of Decentralization Reform in Japan,The 79th Annual Meeting of Japan Society for Occupational Health)

SANGYO EISEIGAKU ZASSHI ◽

10.1539/sangyoeisei.kj00004429642 ◽

2006 ◽

Vol 48 (Special) ◽

pp. 509

Author(s):

K. Matsushita

Keyword(s):

Sleep Apnea ◽

Occupational Health ◽

Annual Meeting ◽

Oral Presentation ◽

Sleep Disordered Breathing ◽

Sleep Apnea Syndrome ◽

Japan Society ◽

Apnea Syndrome ◽

Decentralization Reform ◽

Disordered Breathing

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Improved Behavior and Sleep After Adenotonsillectomy in Children With Sleep-Disordered Breathing: Long-term Follow-up

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archoto.2009.74 ◽

2009 ◽

Vol 135 (7) ◽

pp. 642-646 ◽

Cited By ~ 27

Author(s):

J. L. Wei ◽

J. Bond ◽

M. S. Mayo ◽

H. J. Smith ◽

M. Reese ◽

...

Keyword(s):

Sleep Disordered Breathing ◽

Long Term Follow Up ◽

Disordered Breathing

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Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) Database

Endocrine Related Cancer ◽

10.1530/erc-17-0253 ◽

2017 ◽

Vol 24 (10) ◽

pp. 505-518 ◽

Cited By ~ 67

Author(s):

Patrick Petrossians ◽

Adrian F Daly ◽

Emil Natchev ◽

Luigi Maione ◽

Karin Blijdorp ◽

...

Keyword(s):

Diabetes Mellitus ◽

Thyroid Nodules ◽

Sleep Apnea Syndrome ◽

Multiple Treatment ◽

Long Term Follow Up ◽

Study Population ◽

Apnea Syndrome ◽

Over Time

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Acromegaly Survey (LAS) Database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The following results were obtained at diagnosis. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs 46.4 years; P < 0.001). The median delay from first symptoms to diagnosis was 2 years longer in females (P = 0.015). Ages at diagnosis and first symptoms increased significantly over time (P < 0.001). Tumors were larger in males than females (P < 0.001); tumor size and invasion were inversely related to patient age (P < 0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (P < 0.001). GH was inversely related to age in both sexes (P < 0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6–4.4% had experienced a fracture. In conclusion, this study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis.

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