scholarly journals Improved Behavior and Sleep After Adenotonsillectomy in Children With Sleep-Disordered Breathing: Long-term Follow-up

2009 ◽  
Vol 135 (7) ◽  
pp. 642-646 ◽  
Author(s):  
J. L. Wei ◽  
J. Bond ◽  
M. S. Mayo ◽  
H. J. Smith ◽  
M. Reese ◽  
...  
2001 ◽  
Vol 2 (6) ◽  
pp. 511-516 ◽  
Author(s):  
Sonia Ancoli-Israel ◽  
Philip Gehrman ◽  
Daniel F. Kripke ◽  
Carl Stepnowsky ◽  
William Mason ◽  
...  

2005 ◽  
Vol 12 (6) ◽  
pp. 632-637 ◽  
Author(s):  
Dominique A Cadilhac ◽  
Rachel D Thorpe ◽  
Dora C Pearce ◽  
Maree Barnes ◽  
Peter D Rochford ◽  
...  

2002 ◽  
Vol 127 (3) ◽  
pp. 230-234 ◽  
Author(s):  
Kasey K. Li ◽  
Nelson B. Powell ◽  
Robert W. Riley ◽  
Christian Guilleminault

OBJECTIVE: Our goal was to evaluate the long-term outcomes of temperature-controlled radiofrequency reduction of the tongue base in sleep-disordered breathing. METHODS: The 18 patients from our initial pilot study were reevaluated. Clinical examinations, polysomnography (PSG), questionnaires, visual analog scales, and a comparative SF-36 were used to assess long-term outcomes. RESULTS: Sixteen of the original 18 patients completed this study; 2 patients were lost to follow-up. The mean follow-up was 28 months. There was a mean weight increase of 3.1 ± 7.9 kg. The original pretreatment Respiratory Disturbance Index (RDI) was a mean of 39.5 with a mean mean oxygen saturation nadir (LSAT) of 81.9%, and the posttreatment RDI was a mean of 17.8 with a mean LSAT of 88.3%. Follow-up PSG data showed a persistent improvement of the mean Apnea Index compared with pretreatment (5.4 vs 22.1) without significant changes compared with posttreatment (4.1). However, there were changes in the follow-up Hypopnea Index (HI) of 22.9 compared with the pretreatment and posttreatment HI values of 17.4 and 13.6, respectively. This resulted in a relapse of the RDI from a posttreatment value of 17.8 to 28.7. The LSAT also worsened from 88.3% to 85.8%. However, there was no significant deterioration in the quality-of-life measurements by SF-36 or in daytime sleepiness by Epworth Sleepiness Scale. CONCLUSION: The success of temperature-controlled radiofrequency tongue base reduction for sleep-disordered breathing may reduce with time. PSG demonstrated that long-term relapse is primarily reflected in the HI without significant detrimental effects on the patient's quality of life (SF-36) and sleepiness (Epworth Sleepiness Scale). Continual evaluation of this treatment modality is warranted.


2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.


2001 ◽  
Vol 120 (5) ◽  
pp. A397-A397
Author(s):  
M SAMERAMMAR ◽  
J CROFFIE ◽  
M PFEFFERKORN ◽  
S GUPTA ◽  
M CORKINS ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A204-A204
Author(s):  
B GONZALEZCONDE ◽  
J VAZQUEZIGLESIAS ◽  
L LOPEZROSES ◽  
P ALONSOAGUIRRE ◽  
A LANCHO ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A754-A755 ◽  
Author(s):  
H ALLESCHER ◽  
P ENCK ◽  
G ADLER ◽  
R DIETL ◽  
J HARTUNG ◽  
...  

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