High Concentrations of Eosinophil Cationic Protein and Eosinophil Protein X in Eosinophilic Pleural Effusions

CHEST Journal ◽  
1993 ◽  
Vol 103 (2) ◽  
pp. 475-478 ◽  
Author(s):  
Tom Pettersson ◽  
Henrik Riska ◽  
Seppo Sutinen ◽  
Matti Klockars ◽  
Christer Peterson
Keyword(s):  
Eosinophil Cationic Protein ◽  
Pleural Effusions ◽  
Cationic Protein ◽  
Protein X ◽  
High Concentrations

scholarly journals In vitroRelease of Eosinophil Proteins in Allergic and Atopic Dermatitis Patients

1994 ◽  
Vol 3 (3) ◽  
pp. 223-227 ◽  
Author(s):  
L. K. Poulsen ◽  
C. M. Reimert ◽  
C. Bindslev-Jensen
Keyword(s):  
Atopic Dermatitis ◽  
Eosinophil Cationic Protein ◽  
Coagulation Cascade ◽  
Clotting Time ◽  
Cationic Protein ◽  
Protein X ◽  
Inhalant Allergy ◽  
Different Levels ◽  
Increased Susceptibility

To investigate whether eosinophils are stimulatedin vivoor have acquired an increased susceptibility to stimuli from the coagulation cascade, the release of eosinophil proteins was compared for three groups of donors with different levels of serum IgE. (1) with atopic dermatitis (s-IgE > 5000 IU/ml,n= 11); (2) with inhalant allergy (200 < s-IgE < 2 000 IU/ml,n= 10); and (3) non-allergic (s- IgE < 100 IU/ml,n= 10). The levels of eosinophil cationic protein and eosinophil protein X (ECP, EPX) were determined in serum (clotting time = 2.0 h) and plasma. Serum and plasma ECP in normal donors demonstrated large intra-personal variations (C.V. 50–80%), but serum-ECP (mean 8.1 ng/ml) was clearly distinguishable from plasma ECP (mean 1.0 ng/ml) by a factor of 8 (range: 5.6–11.6). The ECP released during clotting was markedly increased in the atopic dermatitis group (serum:plasma ratio 13.5,p<0.003) compared with the other groups (6.7 and 5.6). EPX, having a higher plasma level, demonstrated a less pronounced release (serum: plasma ratios 2.0, 1.7 and 1.4), with no statistical difference between donor groups. Considering all donors together the levels of ECP and EPX in plasma and in serum were correlated to the number of eosinophils (coefficients of correlation 0.54-0.58,p<0.002).

Eosinophil cationic protein and eosinophil protein X in the nasal lavage of children during the first 4 weeks of life

Allergy ◽  
2000 ◽  
Vol 55 (12) ◽  
pp. 1121-1126 ◽  
Author(s):  
G. Halmerbauer ◽  
C. Gartner ◽  
D. Koller ◽  
M. Schierl ◽  
J. Kühr ◽  
...  
Keyword(s):  
Eosinophil Cationic Protein ◽  
Nasal Lavage ◽  
Cationic Protein ◽  
Protein X

Urinary leukotriene E4, eosinophil protein X, and nasal eosinophil cationic protein are not associated with respiratory symptoms in 1-year-old children

Allergy ◽  
2001 ◽  
Vol 56 (9) ◽  
pp. 883-888 ◽  
Author(s):  
C. Wojnarowski ◽  
G. Halmerbauer ◽  
E. Mayatepek ◽  
C. Gartner ◽  
T. Frischer ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Protein X

Serum eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in childhood asthma: The influence of atopy

1998 ◽  
Vol 25 (3) ◽  
pp. 167-174 ◽  
Author(s):  
Sami Remes ◽  
Matti Korppi ◽  
Kyllikki Remes ◽  
Kari Savolainen ◽  
Ilkka Mononen ◽  
...  
Keyword(s):  
Childhood Asthma ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Protein X
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