Signs and Symptoms of Multiple Sclerosis

2005 ◽  
pp. 1-14
Author(s):  
Stanley Noort
Keyword(s):  
Multiple Sclerosis ◽  
Signs And Symptoms

scholarly journals Multiple Sclerosis Of The Spinal Cord: Is Gadolinium Irreplaceable In Assessing Lesion Activity?

2013 ◽  
Vol 59 (3) ◽  
pp. 158-161
Author(s):  
Constantina Andrada Treabă ◽  
M Buruian ◽  
Rodica Bălașa ◽  
Maria Daniela Podeanu ◽  
I P Simu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Signs And Symptoms ◽  
Magnetic Resonance Images ◽  
Type I ◽  
Focal Lesions ◽  
Spinal Cord Lesions ◽  
Active Lesion

Abstract Purpose: To evaluate the relationship between the T2 patterns of spinal cord multiple sclerosis lesions and their contrast uptake. Material and method: We retrospectively reviewed the appearance of spinal cord lesions in 29 patients (with relapsing-remitting multiple sclerosis) who had signs and symptoms of myelopathy on neurologic examination and at least one active lesion visualized on magnetic resonance examinations performed between 2004 and 2011. We correlated the T2 patterns of lesions with contrast enhancement and calculated sensitivity and specificity in predicting gadolinium enhancement. Results: Only focal patterns consisting of a lesion’s center homogenously brighter than its periphery on T2-weighed images (type I) correlated significantly with the presence of contrast enhancement (p = 0.004). Sensitivity was 0.307 and specificity 0.929. In contrast, enhancement was not significantly related to uniformly hyperintense T2 focal lesions (type II) or diffuse (type III) pattern defined as poorly delineated areas of multiple small, confluent, subtle hyperintense T2 lesions (p > 0.5 for both). Conclusions: We believe that information about the activity of multiple sclerosis spinal cord lesions in patients with myelopathy may be extracted not only from contrast enhanced, but also from non-enhanced magnetic resonance images.

Assessment and Treatment of Sexual Dysfunction in Multiple Sclerosis

2016 ◽  
Author(s):  
Frederick W. Foley
Keyword(s):  
Multiple Sclerosis ◽  
Sexual Dysfunction ◽  
Patient Population ◽  
Behavioral Interventions ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
Assessment And Treatment ◽  
Pharmacologic Agents

This chapter discusses the signs and symptoms of sexual dysfunction that are common in persons with multiple sclerosis. The epidemiology of sexual dysfunction in this patient population is presented, along with techniques and instruments for screening for sexual dysfunction. Definitions of primary, secondary, and tertiary sexual dysfunction are reviewed, and a detailed discussion of treatment strategies is presented, including pharmacologic agents, devices, and behavioral interventions.

Presenting signs and symptoms in multiple sclerosis

2009 ◽  
Vol 73 (3) ◽  
pp. 269-272 ◽  
Author(s):  
E. A. C. M. Sanders ◽  
E. L. E. M. Bollen ◽  
E. A. Velde
Keyword(s):  
Multiple Sclerosis ◽  
Signs And Symptoms

Classification of patients with a clinically isolated syndrome based on signs and symptoms is supported by magnetic resonance imaging results

2007 ◽  
Vol 13 (6) ◽  
pp. 717-721 ◽  
Author(s):  
J.M. Nielsen ◽  
B. Moraal ◽  
C.H. Polman ◽  
P. Poppe ◽  
M. de Vos ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Classification System ◽  
Signs And Symptoms ◽  
First Episode ◽  
Clinical Classification ◽  
Resonance Imaging ◽  
Imaging Results ◽  
Symptoms And Signs

Background Recently, a clinical classification system was described to determine whether symptoms and signs of patients presenting with a first episode suggestive of multiple sclerosis (MS) indicate the presence of monofocal or multifocal disease. Objectives To evaluate the value of this new classification system by comparing the results with those of simultaneously obtained magnetic resonance imaging (MRI) scans. Methods The 487 patients, randomised in the BENEFIT study, were centrally assessed using the new system and classified as monofocal or multifocal, based on clinical information by two neurologists masked for the MRI results. MRI analyses were performed by expert readers masked for the clinical classification. Results Patients classified as multifocal had more T2 hyperintense (median: 21 versus 15.5) and more T1 hypo-intense lesions (median: 2 versus 1) than those classified as monofocal. Patients classified at the local site as having evidence of a single clinical lesion, but reclassified centrally as having a clinical multifocal central nervous system presentation, had more T2 lesions than monofocal patients. In addition, patients with a multifocal presentation more often fulfilled the MRI criteria for dissemination in space, as incorporated in the International Panel (IP) diagnostic criteria for MS. Conclusion These data provide justification for the recently proposed clinical classification system to be used in patients who present with a first episode suggestive of MS, in that `multifocal', based on symptoms and signs, is associated with more lesions on MRI. Multiple Sclerosis 2007; 13: 717-721. http://msj.sagepub.com

Primary Care for the Multiple Sclerosis Patient

2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Vijay Aswani
Keyword(s):  
Multiple Sclerosis ◽  
Primary Care ◽  
Multiple Sclerosis Patient ◽  
Medical Home ◽  
Signs And Symptoms ◽  
Patient Centered Medical Home ◽  
Preventative Care ◽  
Patient Centered ◽  
Primary Care Practitioners ◽  
Immunosuppression Therapy

Multiple sclerosis is the commonest non-traumatic disabling disease that affects young adults. The presenting signs and symptoms include several common symptoms seen in primary care. It therefore behooves primary care practitioners to recognize the disease’s presentation, mimicking diagnoses and initial workup. Management of many of the symptoms of disease exacerbations are within the purview of the primary care provider. Co-management of the patient with multiple sclerosis with a neurologist improves patient care and provides a context for management of co-morbidities. The patient-centered medical home provides many services and resources that can be of use to a multiple sclerosis patient. Vaccinations and other preventative care are important in the care of the multiple sclerosis patient, particularly those on immunosuppression therapy for their disease.

Paroxysmal signs and symptoms in multiple sclerosis

Neurology ◽  
1974 ◽  
Vol 24 (5) ◽  
pp. 458-458 ◽  
Author(s):  
C. E. MILEY ◽  
F. M. FORSTER
Keyword(s):  
Multiple Sclerosis ◽  
Signs And Symptoms

scholarly journals Functional impairments in white matter syndrome of neuropsychiatric systemic lupus erythematosus are similar to those observed in patients with multiple sclerosis

2012 ◽  
Vol 70 (10) ◽  
pp. 769-773 ◽  
Author(s):  
Denise Sisterolli-Diniz ◽  
Aline de Oliveira ◽  
Daiany Silva de Paula ◽  
Rosangela Vieira Rodrigues ◽  
Nilzio Antônio da Silva
Keyword(s):  
Multiple Sclerosis ◽  
Systemic Lupus Erythematosus ◽  
White Matter ◽  
Lupus Erythematosus ◽  
Signs And Symptoms ◽  
Functional System ◽  
Functional Impairments ◽  
Systemic Lupus ◽  
Symptoms Of Depression ◽  
Neuropsychiatric Systemic Lupus Erythematosus

OBJECTIVE: In order to compare white matter syndrome of neuropsychiatric systemic lupus erythematosus (NPSLE) and multiple sclerosis (MS), an assessment on demographic, medical history, and clinical data was proposed. METHODS: Sixty-four patients with NPSLE and 178 with MS answered a questionnaire and were evaluated regarding functional system, expanded disability status scale (EDSS), Beck depression inventory (BDI), and Beck anxiety inventory (BAI). RESULTS: The prevalence of autoimmune diseases and altered consciousness was similar in both groups, however it was higher than in the general population. Systemic signs and symptoms occurred from 2.9 to 61.9% of the MS cases, while neurological signs and symptoms occurred in 9.4 to 76.4% of the NPSLE ones. The motor, visual, and mental systems were the most affected in both diseases. The BDI in NPSLE had higher scores and the BAI in MS. CONCLUSIONS: The functional impairments in NPSLE were similar to those of MS, although greater impairment of the functional systems of cerebellar, sensitivity, and sphincters occurred in MS cases, and greater symptoms of depression, anxiety, and headache also occurred in it.

scholarly journals Rituximab induced cytokine release syndrome in an MS patient: a case report

2021 ◽  
Author(s):  
Masoud Etemadifar ◽  
Mehri Salari ◽  
Mahdieh Saeri ◽  
Amirhossein Akhavan Sigari ◽  
Sara Ebrahimi
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Side Effect ◽  
Signs And Symptoms ◽  
Common Side Effect ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Relapsing Remitting ◽  
History Of ◽  
Relapsing Remitting Multiple Sclerosis

Rituximab use in multiple sclerosis has been promising. Cytokine release syndrome (CRS) is a common side effect of rituximab in patients with lymphoma. We report a case of a 44-year-old man with a history of relapsing-remitting multiple sclerosis, who presented with signs and symptoms consistent with CRS after rituximab initiation.

Caveat Computator

1967 ◽  
Vol 6 (03) ◽  
pp. 127-130
Author(s):  
J. F. Kuhtzke
Keyword(s):  
Multiple Sclerosis ◽  
Quality Control ◽  
Medical Research ◽  
Medical Diagnosis ◽  
Signs And Symptoms ◽  
Black Box ◽  
The Body ◽  
Data Handling ◽  
Input And Output ◽  
Medical Reports

Electronic data processing by computers is playing an increasing role in medicine as elsewhere in our society. The use of computers in medical research too often leads to the presentation of conclusions impossible to substantiate from the text. Computers require even more attention to research design and »quality control« of data-handling than non-electronic measures, since the basic data are often too massive for presentation, and the »black box« nature of the computer effectively hides the transitions between input and output. Electronic retrieval of data from narrative medical reports appears to be unfeasible in any routine setting, and medical diagnosis by computer appears totally impractical: as exemplified in multiple sclerosis, the responses of the body to varied noxae are too limited to provide sufficiently discriminatory signs and symptoms or patterns of same to permit computer appraisal.

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