Recent Achievements in the Improvement of Oral Bioavailability of Curcumin and its Health Benefits

2021 ◽  
pp. 1-6
Author(s):  
Mona Miran ◽  
Maryam Salami ◽  
Zahra Emam-Djomeh ◽  
Seyed-Behnam Ghaffari
Keyword(s):  
Oral Bioavailability ◽  
Health Benefits

Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of retinal protective carotenoid lutein in rat model

2021 ◽  
Author(s):  
Veeresh B Toragall ◽  
Twinkle Godhwani ◽  
V Baskaran ◽  
Naveen Jayapala
Keyword(s):  
Linoleic Acid ◽  
Oral Bioavailability ◽  
Mixed Micelles ◽  
Water Solubility ◽  
Health Benefits ◽  
Aqueous Solubility ◽  
Mean Size ◽  
The Mean

Abstract There is excessive interest in emerging colloidal delivery systems to enhance the water solubility and oral bioavailability of lutein, which is a hydrophobic carotenoid claimed to possess health benefits. The present study aimed to design lutein-enriched nanoemulsions with improved physicochemical properties and to achieve various health benefits of lutein. The prepared lutein nanoemulsion was characterized, and its bioavailability was examined in vitro (simulated gastrointestinal digestion) and in vivo. The mean size, PDI and zeta potential of the lutein nanoemulsion were 110 ± 8 nm, 0.271 and 36 ± 2 mV, respectively. Furthermore, TEM examination revealed that the particles are nanosized and spherical in shape. Notably, the aqueous solubility of the nanoemulsion was 726-fold higher than that of free lutein. The composite nanoemulsion also showed exceptionally higher (87.4%) in vitro bioaccessibility than that of nonencapsulated or free lutein (15%). The in vivo bioavailability of lutein nanoemulsion (112.6 ng/mL) was much higher than that of nonencapsulated lutein (48.6 ng/ml) and mixed micelles (68.5 ng/mL), and the tissue distribution pattern of lutein nanoemulsion showed higher lutein accumulation in the liver (2.80- and 1.70-fold) and eye (1.91- and 1.48-fold) compared to free lutein and mixed micelle-fed groups. These results suggested that oleic acid-linoleic acid composite nanoemulsions may be a promising delivery system for lutein and may help enhance the solubility, oral bioavailability and bioefficacy of lutein and could be used as an ingredient for the formulation of beverages or functional foods.

scholarly journals Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats

2015 ◽  
Vol 113 (5) ◽  
pp. 749-757 ◽  
Author(s):  
Jatinder Kaur Mukker ◽  
Ravi Shankar Prasad Singh ◽  
Alister D. Muir ◽  
Ed S. Krol ◽  
Jane Alcorn
Keyword(s):  
Oral Bioavailability ◽  
Health Benefits ◽  
Wistar Rat ◽  
Volume Of Distribution ◽  
Systemic Clearance ◽  
Secoisolariciresinol Diglucoside ◽  
Serum Samples ◽  
Primary Metabolites ◽  
Flaxseed Lignans ◽  
Male Wistar Rats

Consumption of flaxseed lignans is associated with various health benefits; however, little is known about the bioavailability of purified lignans in flaxseed. Data on their bioavailability and hence pharmacokinetics (PK) are necessary to better understand their role in putative health benefits. In the present study, we conducted a comparative PK analysis of the principal lignan of flaxseed, secoisolariciresinol diglucoside (SDG), and its primary metabolites, secoisolariciresinol (SECO), enterodiol (ED) and enterolactone (EL) in rats. Purified lignans were intravenously or orally administered to each male Wistar rat. SDG and its primary metabolites SECO, ED and EL were administered orally at doses of 40, 40, 10 and 10 mg/kg, respectively, and intravenously at doses of 20, 20, 5 and 1 mg/kg, respectively. Blood samples were collected at 0 (pre-dose), 5, 10, 15, 20, 30 and 45 min, and at 1, 2, 4, 6, 8, 12 and 24 h post-dosing, and serum samples were analysed. PK parameters and oral bioavailability of purified lignans were determined by non-compartmental methods. In general, administration of the flaxseed lignans SDG, SECO and ED demonstrated a high systemic clearance, a large volume of distribution and short half-lives, whereas administration of EL at the doses of 1 mg/kg (intravenously) and 10 mg/kg (orally administered) killed the rats within a few hours of dosing, precluding a PK analysis of this lignan. PK parameters of flaxseed lignans exhibited the following order: systemic clearance, SDG < SECO < ED; volume of distribution, SDG < SECO < ED; half-life, SDG < ED < SECO. The percentage of oral bioavailability was 0, 25 and < 1 % for SDG, SECO and ED, respectively.

Denosumab's Bone Health Benefits Persist After 5 Years

2011 ◽  
Vol 44 (8) ◽  
pp. 48
Author(s):  
HEIDI SPLETE
Keyword(s):  
Bone Health ◽  
Health Benefits

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Organically Produced Plant Foods - Evidence of Health Benefits

2003 ◽  
Vol 53 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Bengt Lundegårdh ◽  
Anna Mårtensson
Keyword(s):  
Health Benefits ◽  
Plant Foods

Organically Produced Plant Foods - Evidence of Health Benefits

2003 ◽  
Vol 53 (1) ◽  
pp. 1-1 ◽  
Author(s):  
Bengt Lundegårdh ◽  
Anna Mårtensson
Keyword(s):  
Health Benefits ◽  
Plant Foods

The Colorado Clinical Psychology/Expanded Mental Health Benefits Experiment: An introductory commentary.

1983 ◽  
Vol 38 (12) ◽  
pp. 1274-1278 ◽  
Author(s):  
Russell J. Bent ◽  
Joan G. Willens ◽  
Carol L. Lassen
Keyword(s):  
Mental Health ◽  
Clinical Psychology ◽  
Health Benefits ◽  
Mental Health Benefits

Exercise Motivation and Mental Health Benefits

PsycCRITIQUES ◽  
2013 ◽  
Vol 58 (24) ◽  
Author(s):  
Jennifer J. Waldron
Keyword(s):  
Mental Health ◽  
Health Benefits ◽  
Exercise Motivation ◽  
Mental Health Benefits
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