bone health
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Author(s):  
Ehsaneh Taheri ◽  
Armita Mahdavi-Gorabi ◽  
Jalal Moludi ◽  
Hamid Asayesh ◽  
Mostafa Qorbani

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 392
Author(s):  
Taeyoung Yang ◽  
So-Young Lee ◽  
Kyung-Chae Park ◽  
Sin-Hyung Park ◽  
Jaiwoo Chung ◽  
...  

Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.


Climacteric ◽  
2022 ◽  
pp. 1-11
Author(s):  
R. F. Vasanwala ◽  
L. Gani ◽  
S. B. Ang
Keyword(s):  

Author(s):  
Kaiwen Xue ◽  
Ruijie Tao ◽  
Qi Wu ◽  
Lei Zhang ◽  
Zhongyang Sun ◽  
...  

The human gut microbiota has been proven to have great effects on the regulation of bone health. However, the association between gut microbiota and particle-induced osteolysis, which is the primary cause of aseptic loosening, is still unknown. In this study, we used a combination of wide-spectrum antibiotics to eliminate the majority of gut microbiota and found that reduction of gut commensal bacteria significantly alleviated the progression of osteolysis, in which anaerobe was the biggest culprit in the exacerbation of osteolysis. Furthermore, colonization of enteropathogenic Escherichia coli (EPEC), a subspecies of anaerobe, could promote the development of particle-induced osteolysis by increasing the secretion of peripheral 5-hydroxytryptamine (5-HT) from the colon. Elevated 5-HT level decreased the phosphorylation of CREB and inhibited the proliferation of osteoblasts. Collectively, these results indicated EPEC colonization suppressed the bone formation and aggravated particle-induced osteolysis in vivo. Thus, clearance of EPEC is expected to become a potential preventive approach to treat debris-induced osteolysis and aseptic loosening.


2022 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Osman Kipoğlu ◽  
Esin Karakılıç Özturan ◽  
Orhan Coşkun ◽  
Ayşe Öztürk ◽  
Edibe Pembegül Yıldız ◽  
...  

Author(s):  
Caterina Mosca ◽  
Fanney Thorsteinsdottir ◽  
Bo Abrahamsen ◽  
Jüri Johannes Rumessen ◽  
Mina Nicole Händel

Author(s):  
Yasser El Miedany
Keyword(s):  

Author(s):  
Chien-Lin Lu ◽  
Chia-Chao Wu ◽  
Yi-Chou Hou ◽  
Cai-Mei Zheng ◽  
Kuo-Cheng Lu

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