scholarly journals Photophysical Studies on Drug Conjugates of Stavudine/Zidovudine and 1,8-Naphthalimide in Different Solvent Systems

2021 ◽  
Vol 33 (11) ◽  
pp. 2729-2736
Author(s):  
Nidhi Singh ◽  
Farha Naaz ◽  
Rajesh Verma ◽  
Shivendra Singh ◽  
Ramendra K. Singh
Keyword(s):  
Room Temperature ◽  
Aqueous Media ◽  
Fluorescence Measurement ◽  
Drug Conjugates ◽  
Coupling Reagent ◽  
Body Level ◽  
Photophysical Studies ◽  
Solvent Systems ◽  
Hiv Drugs ◽  
Anti Hiv

A number of fluorescent conjugates of popular anti-HIV drugs 2′,3′-didehydro-2′,3′-dideoxythymidine (stavudine, d4T) and 3′-azido-3′-deoxythymidine (zidovudine, AZT) with 1,8-naphthalimide were synthesized using the coupling reagent dicyclohexylcarbodiimide (DCC) in the presence of 4-dimethylaminopyridine (DMAP) and N,N-dimethylformamide (DMF) as solvent at room temperature. The steady-state fluorescence measurement studies on these conjugates showed solvatochromic effect. Further, the fluorescence of drug conjugates was recorded in the presence of ions like Na+ and K+ at body level concentration of 135-145 mmol L-1 and 3.6-5.1 mmol L-1, respectively, in phosphate buffer at pH 7.4 in aqueous media. It was observed that the drug conjugates did not show appreciable fluorescence quenching in presence of ions and buffer.

Two New Anti-HIV Drugs Provide Effective Combo

2005 ◽  
Vol 35 (3) ◽  
pp. 32
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Hiv Drugs ◽  
Anti Hiv

Temperature Dependence of the Self-Assembled Styrene Based Random Ionomers in Aqueous Solution

2003 ◽  
Vol 775 ◽  
Author(s):  
Sung-Hwa Oh ◽  
Ju-Myung Song ◽  
Joon-Seop Kim ◽  
Hyang-Rim Oh ◽  
Jeong-A Yu
Keyword(s):  
Partition Coefficients ◽  
Room Temperature ◽  
Aqueous Media ◽  
The Self ◽  
Spectroscopic Methods ◽  
Ion Content ◽  
Repeat Units ◽  
Notable Effect ◽  
Order Of Magnitude ◽  
Experimental Errors

AbstractSolution behaviors of poly(styrene-co-sodium methacrylate) were studied by fluorescence spectroscopic methods using pyrene as a probe. The mol% of methacrylate was in the range 3.6–9.4. Water and N,N-dimethylforamide(DMF) mixture was used as a solvent (DMF/water = 0.2 mol %). The critical micelle (or aggregation) concentrations of ionomers and the partition coefficients of pyrene were obtained the temperature range 10–80°C. At room temperature, the values of CMCs (or CACs) were in the range 4.7 ×10-6 5.3 ×10-6 g/mL and we could not find any notable effect of the content of ionic repeat units within the experimental errors. Unlike CMCs, as the ion content increased, partitioning of pyrene between the hydrophobic aggregates and an aqueous media decreased from 1.5 ×105 to 9.4 ×104. As the temperature increased from 10 to 80 °C, the values of CMCs increased less than one order of magnitude. While, the partition coefficients of pyrene decreased one order of magnitude and the effect of the ion content became negligible.

Multiscale Mapping of AIDS in U.S. Countries vs Anti-HIV Drugs Activity with Complex Networks and Information Indices

2015 ◽  
Vol 10 (5) ◽  
pp. 639-657 ◽  
Author(s):  
Diana Maria Herrera-Ibata ◽  
Ricardo Alfredo Orbegozo-Medina ◽  
Humberto Gonzalez-Diaz
Keyword(s):  
Complex Networks ◽  
Information Indices ◽  
Hiv Drugs ◽  
Anti Hiv

Lipid Based Nanocarriers for Delivery of Anti-HIV Drugs: A Mini Review

2018 ◽  
Vol 8 (2) ◽  
pp. 172-185
Author(s):  
Diksha Mishra ◽  
Anil B. Jindal
Keyword(s):  
Hiv Drugs ◽  
Anti Hiv

scholarly journals Recent Advancements in Polythiophene-Based Materials and Their Biomedical, Geno Sensor and DNA Detection

2021 ◽  
Vol 22 (13) ◽  
pp. 6850
Author(s):  
Seyyed Mojtaba Mousavi ◽  
Seyyed Alireza Hashemi ◽  
Sonia Bahrani ◽  
Khadije Yousefi ◽  
Gity Behbudi ◽  
...  
Keyword(s):  
Biomedical Engineering ◽  
High Efficiency ◽  
Polymeric Materials ◽  
The Novel ◽  
Electrode Coating ◽  
Effective Response ◽  
Hiv Drugs ◽  
New Generation ◽  
New Compounds ◽  
Anti Hiv

In this review, the unique properties of intrinsically conducting polymer (ICP) in biomedical engineering fields are summarized. Polythiophene and its valuable derivatives are known as potent materials that can broadly be applied in biosensors, DNA, and gene delivery applications. Moreover, this material plays a basic role in curing and promoting anti-HIV drugs. Some of the thiophene’s derivatives were chosen for different experiments and investigations to study their behavior and effects while binding with different materials and establishing new compounds. Many methods were considered for electrode coating and the conversion of thiophene to different monomers to improve their functions and to use them for a new generation of novel medical usages. It is believed that polythiophenes and their derivatives can be used in the future as a substitute for many old-fashioned ways of creating chemical biosensors polymeric materials and also drugs with lower side effects yet having a more effective response. It can be noted that syncing biochemistry with biomedical engineering will lead to a new generation of science, especially one that involves high-efficiency polymers. Therefore, since polythiophene can be customized with many derivatives, some of the novel combinations are covered in this review.

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