A STUDY OF CORRELATION OF VISUAL FIELD CHANGES BY HUMPHREY’S AUTOMATED FIELD ANALYSER WITH RETINAL NERVE FIBER LAYER (RNFL) DEFECTS ON OPTICAL COHERENCE TOMOGRAPHY (OCT) IN PRIMARY OPEN ANGLE GLAUCOMA (POAG)

Background: To correlate the findings of optical coherence tomography (OCT) evaluation of retinal nerve fiber layer (RNFL) thickness in primary open angle glaucoma, ocular hypertensive and normal eyes.Methods: A 34 consecutive normal, 26 consecutive ocular hypertensives and 40 consecutive glaucomatous eyes underwent a complete ophthalmic examination, including applanation tonometry, disc evaluation, gonioscopy and perimetry. Thickness of the RNFL around the optic disc was determined with 3.4 mm diameter-wide 3D 2000 TOPCON OCT. Average and segmental RNFL thickness values were compared among all groups.Results: Of the 100 eyes enrolled, the mean RNFL thickness was significantly less in glaucomatous eyes (83.165±15.938) than in normal’s (102.42±15.2) and ocular hypertensive’s (100.45±7.38). RNFL, average thicknesses in all four quadrants in POAG patients were significantly decreased compared with the OHT and the control groups.Conclusions: RNFL measurement with SD-OCT could provide important information for detection of early stages of glaucoma. (pre-perimetric glaucoma) as well as help in evaluating progression of glaucoma.

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Study of Retinal Nerve Fiber Layer Thickness by Optical Coherence Tomography in Primary Open Angle Glaucoma, Glaucoma Suspect and Normal Nepalese Population

Nepal Medical College Journal ◽

10.3126/nmcj.v22i3.32635 ◽

2020 ◽

Vol 22 (3) ◽

pp. 135-140

Author(s):

Srijana Thapa Godar ◽

KR Kaini

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Retinal Nerve Fiber

The measurement of retinal nerve fiber layer thickness can help significantly in the early diagnosis of glaucoma and monitoring of its progression. The objective of this study was to compare the retinal nerve fiber layer (RNFL) thickness by optical coherence tomography in primary open angle glaucoma, glaucoma suspects and normal Nepalese population. This was a hospital based cross-sectional study conducted in the Ophthalmology Out Patient Department of Manipal Teaching Hospital, Pokhara. Total 100 numbers of subjects (40 primary open angle glaucoma, 30 glaucoma suspects and 30 normal people) were evaluated. Complete ophthalmological examinations including tonometry, gonioscopy, optical coherence tomography, perimetry were performed. Statistical analysis was carried out using Epi-info 7. The result showed that the average retinal nerve fiber layer (RNFL) thickness was 70.22±12.07μm in right eye and 69.42±11.53μm in left eye in primary open angle glaucoma (POAG), 88.87±10.39μm in right eye and 88.73±9.59μm in left eye in glaucoma suspects (GS) and 94.40±9.21μm in right eye and 94.73±6.76μm in left eye in normal group respectively. The mean RNFL thickness was statistically significant in all three comparison groups except in nasal quadrant. The mean RNFL thickness was statistically significant in two comparison groups except in GS-Normal (nasal and temporal quadrant), GS-POAG (left nasal quadrant) and Normal-POAG (left nasal quadrant). The study concluded that the RNFL thickness is lower in POAG as compared to glaucoma suspects and normal group in the Nepalese population.

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Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.3.1553 ◽

2020 ◽

Vol 36 (3) ◽

Author(s):

Ayesha Saba Naz ◽

Aisha Qamar ◽

Sama Ul Haque ◽

Yawar Zaman ◽

Faisal Faheem

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Lamina Cribrosa ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Retinal Nerve Fiber

Objectives: To calculate the anterior lamina cribrosa depth (ALCD) and lamina cribrosa thickness (LCT) in primary open angle glaucoma (POAG) patients and controls and to correlate lamina cribrosa (LC) parameters to retinal nerve fiber layer thickness (RNFLT) and visual field (VF) defects. Methods: The study was conducted from November 2018 to March 2019. A total of 60 correspondents (30 cases and 30 controls) were assessed for general ophthalmological investigations including intraocular pressure (IOP), axial length AXL, ophthalmoscopy, visual field (VF) testing and spectral domain ocular computed tomography (SDOCT). Results: The mean age of subjects was 62 years (Cases 67.30±1.2, controls 57.32±1.1) with more male participants. Intraocular pressure [IOP (19.85 ±1.4)], AXL (22.85 ± 1.6), VF defects (8.30 ± 4.5), RNFLT (72.58 ± 13.2) and LCT (162.51 ± 64.62) were statistically significant in POAG patients as compared to the controls. Conclusion: A thinner LC in POAG correlated significantly with the RNFLT and VF defects. LC anatomical parameters can be estimated with precision using SDOCT with enhanced depth imaging (EDI). doi: https://doi.org/10.12669/pjms.36.3.1553 How to cite this:Naz AS, Qamar A, Sama-Ul-Haque, Zaman Y, Faheem F. Association of lamina cribrosa morphometry with retinal nerve fiber layer loss and visual field defects in primary open angle glaucoma. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1553 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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