scholarly journals The Link between Cancer, Autoimmunity and Diabetes

Author(s):  
Domina Petric

In cancer, corrupted neoplastic cell successfully evades the immune attack using two main strategies: avoiding the immune recognition and instigating an immunosuppressive tumor microenvironment. Cancer is able to induce immune tolerance and present itself to immune system as normal tissue. There is a defect in immune tolerance: the tolerance is wrongly induced toward cancer. In autoimmune diseases, immune system attacks normal tissue because it fails to recognize its own constituent parts as self. There is a defect in immune tolerance: the tolerance is lost toward normal tissues. In both diseases wrong information in the communication between tissue (neoplastic) cells and immune system is crucial: in cancer, neoplastic cells avoid immune attack, whilst in autoimmune diseases, immune system attacks normal cells. Diabetes mellitus type I and II are associated with an increased risk of developing different types of cancer. Pathogenesis of diabetes mellitus type I and pathogenesis of cancer overlap in genetic, environmental and immunologic factors. Diabetes mellitus type II and obesity can both induce oncogenesis.

2007 ◽  
Vol 2 (04) ◽  
Author(s):  
N Kyriakopoulos ◽  
C Gavala ◽  
I Georgantis ◽  
S Patiakas ◽  
S Tsitlakidou ◽  
...  

1999 ◽  
Vol 52 (3) ◽  
pp. 119-124 ◽  
Author(s):  
A. Galli-Tsinopoulou ◽  
S. Nousia-Arvanitakis ◽  
D. Dracoulacos ◽  
M. Xefteri ◽  
M. Karamouzis

2021 ◽  
Vol 26 (1) ◽  
pp. 20-27
Author(s):  
E. S. Loboda ◽  
L. Yu. Orekhova ◽  
E. V. Grinenko ◽  
A. Yu. Kropotina ◽  
N. A. Iamanidze ◽  
...  

Relevance. At present, the problem of the prevalence of overweight is becoming increasingly important in countries with a high standard of living, especially among the urban population. The social significance of this problem is determined by the threat of the development of diseases of the cardiovascular system, gastrointestinal tract, musculoskeletal system, as well as diabetes mellitus, which in turn are serious risk factors for the development and progression of periodontal pathology. One of the stages in the treatment of periodontal diseases is professional oral hygiene, the tactics of which, the effectiveness and stability of the results obtained also depend on taking into account the individual characteristics of the organism. Objective – to assess the effect of overweight (ICD 10 - K63.5) on the manifestation of periodontal disease and the clinical effectiveness of professional oral hygiene as a stage of initial periodontal therapy in the presence of diabetes mellitus. Materials and methods. The study involved 83 patients with diabetes mellitus type I aged 25 to 45 years with overweight and normal constitution, with chronic generalized periodontitis of mild and moderate severity. All patients underwent a standard complex of professional oral hygiene. Re-examination was carried out after 1 month. Results. The severity of clinical manifestations of periodontitis in patients with diabetes mellitus and overweight was higher than in the group of patients with normal constitution. The analysis of the effectiveness of professional oral hygiene as one of the stages of conservative periodontal therapy revealed differences in the response from the organism as a whole, and periodontal tissues in particular in the examined groups, demonstrating the pathological effect of excess body weight on the decrease in the effectiveness of hygiene measures. Conclusion. The identification of differences in the examined groups confirms the importance of overweight as an aggravating component in patients with periodontal disease and diabetes mellitus type I and dictates the need for a more detailed study of this parameter in the management of patients in this group and predicting treatment results, as well as creates the need for development and implementation of a comprehensive treatment and prevention strategy, including the assessment and monitoring of body mass index, promotion of a healthy lifestyle, elimination of modifiable risk factors.


1986 ◽  
Vol 6 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Sjögren A. ◽  
Edvinsson L. ◽  
Flgrén C.-H. ◽  
Abdulla M.

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