scholarly journals Agressive central giant cell granuloma of the mandible: case report

2015 ◽  
Vol 18 (3) ◽  
pp. 114
Author(s):  
Ana Reis Durão ◽  
José Teixeira Koch ◽  
Marcelo Miranda ◽  
Aline Morosolli Aline
Keyword(s):  
Giant Cell ◽  
Bone Growth ◽  
Anterior Region ◽  
Patient Treatment ◽  
Surgical Removal ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Mandibular Region ◽  
Corticosteroid Injections

<p>Central giant cell granulomas (CGCG) are benign intraosseous proliferative lesions. Usually located are at the anterior region of the maxilla or mandible, although are more frequently found in the mandible. Etiopathogenesis of these lesions has remained unknown, however, some consider them as reparative response rather than neoplastic condition. Clinically CGCG present as asymptomatic, with expansive swelling causing deviation or proliferation of cortical bone. This condition is usually unifocal. Surgical removal is often the preferred treatment. Although nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. This article describes the radiographic features of a large CGCG in the anterior mandibular region seen in a 9 year-old patient. Treatment of this lesion included resection of the anterior region of the mandible and replacement by tibia with bone growth factors.</p><p> </p><p><strong>Keywords</strong>: Central giant cell granuloma; reparative granulomas; mandible; jaws.</p><p><strong> </strong></p>

scholarly journals Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study

2019 ◽  
Vol 14 (2) ◽  
pp. 497-502 ◽  
Author(s):  
Raíssa Pinheiro de Mendonça ◽  
Geovanni Pereira Mitre ◽  
Flavio Henrique Real ◽  
Maria Sueli da Silva Kataoka ◽  
Sérgio de Melo Alves Júnior ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Long Term Follow Up ◽  
Corticosteroid Injections

scholarly journals Correction to: Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long‑Term Follow‑Up Case Study

2021 ◽  
Author(s):  
Raíssa Pinheiro de Mendonça ◽  
Geovanni Pereira Mitre ◽  
Flavio Henrique Real ◽  
Maria Sueli da Silva Kataoka ◽  
Sérgio de Melo Alves Júnior ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Long Term Follow Up ◽  
Corticosteroid Injections

Treatment of a central giant cell granuloma with intralesional corticosteroid

2005 ◽  
Vol 43 (1) ◽  
pp. 74-76 ◽  
Author(s):  
Evandro Neves Abdo ◽  
Luiz César Fonseca Alves ◽  
Alessandra Sabrina Rodrigues ◽  
Ricardo Alves Mesquita ◽  
Ricardo Santiago Gomez
Keyword(s):  
Giant Cell ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid

scholarly journals Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Deepanshu Gulati ◽  
Vishal Bansal ◽  
Prajesh Dubey ◽  
Sanjay Pandey ◽  
Abhinav Agrawal
Keyword(s):  
Primary Hyperparathyroidism ◽  
Giant Cell ◽  
Elevated Serum ◽  
Cortical Plate ◽  
Radiographic Examination ◽  
Surgical Removal ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Posterior Maxilla ◽  
Patient Reported

A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15–30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. Blood tests after histopathology demonstrated elevated serum calcium level and alkaline phosphatase level. Immunoassay of parathyroid hormone (PTH) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed osteoclastic lesions. Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of brown tumour of maxilla was made. The patient underwent partial parathyroidectomy under general anaesthesia to control primary hyperparathyroidism. Surgical removal of the bony lesion was done by curettage. The patient has been followed up for 1 year with no postoperative complications and the lesion healed uneventfully.

Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up

2020 ◽  
Vol 13 (9) ◽  
pp. e237200
Author(s):  
Kumar Nilesh ◽  
Anuj Dadhich ◽  
Rahul Patil
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Ablative Surgery ◽  
Long Term Follow Up ◽  
Intralesional Injections

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

scholarly journals Extensive Aggressive Central Giant Cell Granuloma of the Mandible: Conservative Steroids Treatment in a Pediatric Patient

2017 ◽  
Vol 1 (1) ◽  
pp. s-0037-1601482
Author(s):  
Pietro Boni ◽  
Alberto Bozzetti ◽  
Valeria Morganti ◽  
Giorgio Novelli ◽  
Davide Sozzi
Keyword(s):  
Giant Cell ◽  
Pediatric Patient ◽  
Corticosteroid Injection ◽  
Fibrous Tissue ◽  
Treatment Protocol ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Health Organization

Central giant cell granuloma (CGCG) is a relatively rare intraosseous lesion, described by the World Health Organization as a localized proliferation consisting of fibrous tissue with hemorrhage deposits, the presence of osteoclast-like cells, and reactive bone formation. In this article, the authors present their experience in managing a wide, aggressive CGCG of the whole tooth-bearing mandible in a 9-year-old pediatric patient. The extension of the lesion and the age of the patient have presented a double challenge concerning treatment and outcome. If fact the main objective remains a correct therapeutic treatment, focused on healing the patient and avoiding recurrences, the clinician must be careful in preventing an excessive morbidity. The authors decided to treat the young patient with intralesional corticosteroid therapy, reserving surgery in case of non-response or for subsequent refinements. In this article is presented the authors’ conservative treatment protocol with intralesional corticosteroid injection and their results are compared with literature's data.

scholarly journals Central Giant Cell Granuloma of The Maxilla: Case Report and Literature Review

2021 ◽  
pp. 1-3
Author(s):  
Aicha Ibourk ◽  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Giant Cell ◽  
Fibrous Tissue ◽  
Surgical Removal ◽  
Brown Tumor ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
The Right ◽  
Intraosseous Lesion

Introduction: Central giant cell granuloma (CGCG) is a rare bony lesion in the Head and Neck region. It is a non-odontogenic tumor never seen in any other bone of the skeleton. It is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone. Case Report: We report a case of a 50-year-old female patient with swelling on the right side of face for 4 months. Intraoral examination shows a mass in right lower jaw in the region of 45 and 46 edentulous areas. The swelling had smooth surface, firm and tender on palpation. There was no expansion of lingual region. The radiological examination revealed a well-defined multiloculated expansile and lytic lesion in the right mandible, extending from the 44 to 47 with a resorption of teeth 44. The patient underwent incisional biopsy and the diagnosis of CGCG and brown tumor of hyperparathyroidism was proposed. According to the clinical radiological and biological findings, the diagnosis of CGCG was confirmed. The enucleation of the lesion with the extraction of 44 was done. Discussion: Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the head and neck with potential for aggressive and locally destructive behaviour. Lesions of the maxilla tend to expand more than those of the mandible due to the thinner cortices and spongy tissue of this location. Surgical removal is the most common treatment; however, it may be disfiguring in aggressive cases, especially for lesions located in the maxilla. Alternative treatments, such as intralesional corticosteroid injections, have been performed with satisfactory results.

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