Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.

Surgical management of central giant cell granuloma of mandible and prosthetic rehabilitation in a nine year girl: A case report

Central giant cell granuloma (CGCG) is an uncommon, benign, idiopathic, osteolytic lesion of jaws, histologically characterized by multinucleated giant cells distributed in fibrovascular connective tissue stroma. Accurate diagnosis of the lesion is essential for the successful management and the prognosis of this locally destructive lesion. In this paper, a rare case of large destructive CGCG involving anterior region of mandible, causing expansion of labial cortical plate and mobility of teeth in a nine-year girl is presented. It was treated successfully by enucleation and curettage with satisfactory preservation of the continuity of mandible. Nine months post operatively, the child was rehabilitated with a temporary partial denture to improve esthetics, phonetics and function. One year clinical and radiographic follow up showed new bone formation and no evidence of recurrence.

Central Giant Cell Granuloma of the Mandible: Clinical Observation

The Giant central cell granuloma (GCCG) is a benign intra-osseous lesion of the neo-plastic type. It appears mainly in the mandible, but can be observed in the maxilla and small bones of the hand and foot, with a predilection for the female sex and prevalence at a young age. Its diagnosis is clinical and radiological, confirmed by histological examination. The differential diagnosis is biological because it has a wide range of morphologies and a misinterpretation with other giant cell lesions can often occur. The authors present a case of the Giant central cell granuloma in a 62-year-old woman developing for 3 years after dental extractions. The most favorable treatment for giant cell granulomas is surgical whose main objective is to prevent recurrences.

Dilemma in the Treatment of a Central Giant Cell Granuloma

Management of central giant cell granuloma (CGCG) presents a clinical challenge. While eradicating a lesion known for its high recurrence rate calls for radical surgical approaches, these cause significant esthetic and functional impairment. We present an eight-year-old boy suffering from an extraordinarily large CGCG expanding into the mandible and base of the mouth in the whole anterior region. Combined treatment with surgical intervention and corticosteroid application was successfully applied, and all six attached dental germs could be preserved. Different approaches for clinical management in pediatric cases are discussed.