Role of Locoregional Therapies in Patients With Hepatocellular Cancer Awaiting Liver Transplantation

2020 ◽  
Vol 116 (1) ◽  
pp. 57-67
Author(s):  
Paul J. Thuluvath ◽  
Chau To ◽  
Waseem Amjad
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Locoregional Therapies

scholarly journals The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

2007 ◽  
Vol 89 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Mark D Stringer
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Good Prognosis ◽  
Liver Tumours ◽  
Primary Hepatic Malignancies ◽  
Life Saving ◽  
Time Of Presentation ◽  
Benign Liver ◽  
Hepatic Malignancies

In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver disease – they typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention.

Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West

2012 ◽  
Vol 57 (5) ◽  
pp. 974-979 ◽  
Author(s):  
Quirino Lai ◽  
Alfonso W. Avolio ◽  
Jan Lerut ◽  
Gurusharan Singh ◽  
See Ching Chan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Primary Resection ◽  
East And West

scholarly journals Hepatocellular cancer and liver transplantation: necessity to go from chaos to order

2018 ◽  
Vol 46 (6) ◽  
pp. 552-559
Author(s):  
J. Lerut ◽  
S. Iesari ◽  
M. Foguenne ◽  
K. Ackenin ◽  
Q. Lai
Keyword(s):  
Liver Transplantation ◽  
Treatment Options ◽  
Hepatocellular Cancer ◽  
Inclusion Criteria ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Surgical Disease ◽  
Therapeutic Algorithm ◽  
Locoregional Therapies ◽  
Systemic Therapies

The care for liver-diseased patients presenting with hepatocellular cancer (HCC) is changing rapidly. Many treatment possibilities and caregivers belonging to a multitude of specialities troubled the therapeutic algorithm of the liver cancer patients. HCC in both normal and diseased livers has to be considered firstly as a surgical disease. The possibilities of surgery, including liver resections, as well as liver transplantation, have been underestimated and even been minimalized mainly as a consequence of many studies promoting in an unlimited way all different kinds of locoregional non-surgical and systemic therapies. Locoregional therapies and surgical procedures should not be seen as competing, but as complementary treatment options. Locoregional therapies are of value if surgery is not possible; in the context of transplantation they have an important role as ‘downstaging procedures’ allowing for bringing of transplantable patients into the required inclusion criteria. Systemic therapies and living donor liver transplantation will without any doubt occupy a more important role in the future therapeutic scheme of HCC.

scholarly journals Network pharmacology-based analysis of the role of tacrolimus in liver transplantation

2021 ◽  
Author(s):  
Lijian Chen ◽  
Yuming Peng ◽  
Chunyi Ji ◽  
Miaoxian Yuan ◽  
Qiang Yin
Keyword(s):  
Liver Transplantation ◽  
Network Pharmacology

The role of autonomic dysfunction in predicting 1-year mortality after liver transplantation

2017 ◽  
Vol 37 (8) ◽  
pp. 1239-1248 ◽  
Author(s):  
Kuang-Cheng Chan ◽  
Jia-Rong Yeh ◽  
Wei-Zen Sun
Keyword(s):  
Liver Transplantation ◽  
Autonomic Dysfunction

The Need for Consensus About Liver Transplantation For Patients With Neuropsychiatric Wilson’s Disease

2021 ◽  
pp. 152692482110028
Author(s):  
Alberto Ferrarese ◽  
Patrizia Burra
Keyword(s):  
Liver Transplantation ◽  
Patient Outcomes ◽  
Wilson’S Disease ◽  
Therapeutic Option ◽  
Copper Metabolism ◽  
Wilson's Disease ◽  
Published Data ◽  
Neurological Improvement ◽  
Effective Therapeutic Option

Liver transplantation is considered an effective therapeutic option for Wilson’s disease (WD) patients with hepatic phenotype, since it removes the inherited defects of copper metabolism, and is associated with excellent graft and patient outcomes. The role of liver transplantation in WD patients with mixed hepatic and neuropsychiatric phenotype has remained controversial over time, mainly because of high post-operative complications, reduced survival and a variable, unpredictable rate of neurological improvement. This article critically discusses the recently published data in this field, focussing in more detail on isolated neuropsychiatric phenotype as a potential indication for liver transplantation in WD patients.

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