scholarly journals The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

2007 ◽  
Vol 89 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Mark D Stringer
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Good Prognosis ◽  
Liver Tumours ◽  
Primary Hepatic Malignancies ◽  
Life Saving ◽  
Time Of Presentation ◽  
Benign Liver ◽  
Hepatic Malignancies

In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver disease – they typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention.

scholarly journals 466 Resection or Enucleation for Extremely Giant Hepatic Haemangiomata? A Case Report and Review of The Literature

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
R E Fraser ◽  
G R Layton ◽  
L L Kuan ◽  
A R Dennison
Keyword(s):  
Expectant Management ◽  
Evidence Base ◽  
Primary Treatment ◽  
Cavernous Haemangioma ◽  
Liver Tumours ◽  
Case Presentation ◽  
Best Management ◽  
Anatomical Liver Resection ◽  
Benign Liver

Abstract Background Cavernous hepatic haemangiomas are benign liver tumours and although common when small, giant haemangiomas (usually accepted as being greater than 10cm) are infrequent. Treatment is indicated in patients who are symptomatic or if diagnosis is unclear, although with giant haemangiomas, many support expectant management of asymptomatic lesions due to the risk of major complications. Traditionally hepatic resection has been the primary treatment option for these lesions, but a variety of other techniques, including enucleation, have been described as safe and effective alternatives. There remains equipoise in respect of the best management of giant haemangiomas above 10cm. Cases of such size are rare and so there is a paucity of data available. Case presentation We present a case of a 65-year-old male who underwent successful anatomical liver resection for a 5kg giant cavernous haemangioma of 26cm diameter following its incidental identification during an ultrasound scan. We also discuss and compare the role of resection and enucleation for the treatment of haemangiomata greater than 20cm in diameter. Conclusions This case demonstrates successful resection of an unusually giant haemangioma which, in contrast to the majority of literature, provides a valuable addition to the limited evidence base for management of this condition by anatomical resection.

Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West

2012 ◽  
Vol 57 (5) ◽  
pp. 974-979 ◽  
Author(s):  
Quirino Lai ◽  
Alfonso W. Avolio ◽  
Jan Lerut ◽  
Gurusharan Singh ◽  
See Ching Chan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Primary Resection ◽  
East And West

Liver transplantation for primary hepatic malignancies of childhood: The UNOS experience

2018 ◽  
Vol 53 (1) ◽  
pp. 163-168 ◽  
Author(s):  
Emma C. Hamilton ◽  
Julius Balogh ◽  
Duc T. Nguyen ◽  
Edward A. Graviss ◽  
Andras A. Heczey ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Primary Hepatic Malignancies ◽  
Hepatic Malignancies

Laparoscopic surgery of benign liver tumours

2015 ◽  
Vol 68 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Péter Kupcsulik ◽  
Oszkár Hahn ◽  
Attila Szíjártó ◽  
Attila Zsirka ◽  
Tamás Winternitz ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Liver Tumours ◽  
Benign Liver

Munkahelyünkön 2004–2014 között 273 elektív műtét történt benignus májelváltozás miatt. 83 esetben laparoszkópos (LAP) beavatkozásra került sor: cystafenestratio 52, májresectio 31 esetben történt. A LAP resectiókat hasonló demográfiai és klinikai jellemzőkkel bíró betegek nyitott műtéteivel összehasonlítva megállapítható, hogy a műtéti idő a LAP csoportban (113,7 perc) szignifikánsan hosszabb volt, mint a nyitott műtéteknél (89,5 perc), a kórházi ápolási idő viszont rövidebb (5,8 vs 9,1 nap). Posztoperatív szövődmény a LAP csoportban nem volt, nyitott műtétek után két sebgennyedés, egy UH-vezérelt drainezést igénylő epegyülem fordult elő. A nyitott csoportban 4, a LAP csoportban 3 beteg igényelt transzfúziót. Műtéti halálozás nem volt, reoperációra nem került sor. A közleményben részletezett műtéti technika biztonságos resectiót tesz lehetővé a máj nehezen hozzáférhető, 7–8. szegmentuma területén is. Az eredmények alapján a LAP májresectio megfelelő preoperatív vizsgálatok birtokában választható módszer májdaganatok sebészi kezelésére.

The Role of Histones and Heparin in Sepsis: A Review

2021 ◽  
pp. 088506662199232
Author(s):  
Xiaojuan Zhang ◽  
Xin Li
Keyword(s):  
Septic Shock ◽  
Multiple Organ ◽  
Clinical Settings ◽  
The Past ◽  
Life Saving ◽  
Extracellular Histones ◽  
Sepsis And Septic Shock ◽  
Development And Management ◽  
Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

scholarly journals Network pharmacology-based analysis of the role of tacrolimus in liver transplantation

2021 ◽  
Author(s):  
Lijian Chen ◽  
Yuming Peng ◽  
Chunyi Ji ◽  
Miaoxian Yuan ◽  
Qiang Yin
Keyword(s):  
Liver Transplantation ◽  
Network Pharmacology
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