Nanomaterials based Decontamination Formulation for use in Personal Decontamination Kit Against Chemical Warfare Agents

2017 ◽  
Vol 3 (1) ◽  
pp. 5
Author(s):  
G. K. Prasad ◽  
Anshoo Gautam ◽  
G. M. Kannan ◽  
J. Acharya ◽  
A. K. Gupta ◽  
...  

<p>Present paper relates to nanomaterials based decontamination formulation made up of TiO2, MgO, and ZnO nanoparticles for the use against chemical warfare agents. This decontamination formulation was prepared by mixing 90 per cent of TiO2 nanoparticles of 5-15 nm size range, 8 per cent of MgO nanoparticles of 5-15 nm size range, and 2 per cent of ZnO nanoparticles of 20-30 nm size range. Prepared formulation exhibited 98-99 per cent of physical removal efficiency against contaminated glass, rubber, painted metal, metal surfaces. It efficiently removed chemical warfare agents from contaminated skin thus ameliorating chances of fatality which is expected due to skin penetrated chemical warfare agents. It also chemically degraded 97 per cent of sulphur mustard in 24 h, 99.9 per cent of sarin in 2 h, respectively unlike Fuller’s earth which chemically degraded only 63 per cent of sulphur mustard and 59 per cent of sarin in 24 h .</p>

2010 ◽  
Vol 30 (6) ◽  
pp. 491-498 ◽  
Author(s):  
L. Taysse ◽  
F. Dorandeu ◽  
S. Daulon ◽  
A. Foquin ◽  
N. Perrier ◽  
...  

Using the hairless mouse screening model presented in the companion paper1 the aim of this study was to assess two skin decontaminating systems: Fuller’s earth (FE) and Reactive Skin Decontamination Lotion (RSDL) against two extremely toxic chemical warfare agents that represent a special percutaneous hazard, sulphur mustard (SM) and O-ethyl-S-(2[di-isopropylamino]ethyl)methyl-phosphonothioate (VX). Five minutes after being exposed on the back to either 2 µL of neat sulphur mustard or 50 µg.kg-1 of diluted VX, mice were decontaminated. Both systems were able to reduce blisters 3 days after SM exposure. However, RSDL was found to be more efficient than FE in reducing the necrosis of the epidermis and erosion. In the case of VX exposure, RSDL, whatever the ratio of decontaminant to toxicant used (RSDL 10, 20, 50), was not able to sufficiently prevent the inhibition of plasma cholinesterases taken as a surrogate marker of exposure and toxicity. Only FE reduced significantly the ChE inhibition. Some of these observations are different from our previous results obtained in domestic swine and these changes are thus discussed in the perspective of using SKH-1 hairless mice for the initial in vivo screening of decontaminants.


Toxicology ◽  
2009 ◽  
Vol 262 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Charlotte A. Hall ◽  
Helen L. Lydon ◽  
Christopher H. Dalton ◽  
J. Kevin Chipman ◽  
Robert P. Chilcott ◽  
...  

2018 ◽  
Vol 124 (11) ◽  
Author(s):  
Ying Ci ◽  
Si Wang ◽  
XiaoLong Zhang ◽  
ZhiQiang Fang ◽  
AiMin Ma ◽  
...  

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
N Iwasaki ◽  
S Miyamoto ◽  
K Ishii ◽  
T Takeda ◽  
T Ohto ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document