I have in a previous paper described investigation on the conduction of excitation in
Mimosa pudica
. It was there shown that the various characteristics of the propagation of excitation in the conducting tissue of the plant are in every way similar to those in the animal nerve. Hence it appeared probable that any newly found phenomenon in the one case was likely to lead to the discovery of a similar phenomenon in the other. A problem of great interest which has attracted my attention my attention for several years is the question whether, in a conducting tissue, excitation travels better with or against the direction of an electric current. The experimental difficulties presented in the prosecution of this enquiry are very numerous, the results being complicated by the joint effects of the direction of current on conductivity and of the poles on excitability. As regards the latter, the changes of excitability in the animal nerve under electrotonus have been demonstrated by the well-known experiments of pflüger. In a nerve-and-muscle preparation, the presence of a pole P is shown to induce a variation of excitability of a neighbouring point S. When P is kathode, the excitability of the point S, near it, is enhanced; stimulation of S, previously ineffective, now becomes effective, and the resulting excitation is transmitted to M, causing response of the muscle. Conversely, the application of anode at P causes a depression of excitability of S. Stimulus previously effective now becomes ineffective. In this manner the transmission of excitation may be indirectly modified by the polar variation of excitability of the stimulated point (fig. 1
a
).
Studies on the Irreciprocal Conduction of Excitation. Report IV. On the Critipue of Sherrington's Synaps-theory from the Standpoint of My Experimental Results on the Conduction of Excitation.
