Multi-agent simulated annealing algorithm based on differential perturbation for protein structure prediction problems

Author(s):  
Yiwen Zhong ◽  
Juan Lin ◽  
Qingliang Du ◽  
Limei Wang
Author(s):  
Raghunath Satpathy

Proteins play a vital molecular role in all living organisms. Experimentally, it is difficult to predict the protein structure, however alternatively theoretical prediction method holds good for it. The 3D structure prediction of proteins is very much important in biology and this leads to the discovery of different useful drugs, enzymes, and currently this is considered as an important research domain. The prediction of proteins is related to identification of its tertiary structure. From the computational point of view, different models (protein representations) have been developed along with certain efficient optimization methods to predict the protein structure. The bio-inspired computation is used mostly for optimization process during solving protein structure. These algorithms now a days has received great interests and attention in the literature. This chapter aim basically for discussing the key features of recently developed five different types of bio-inspired computational algorithms, applied in protein structure prediction problems.


2011 ◽  
Vol 383-390 ◽  
pp. 4612-4619 ◽  
Author(s):  
Tadeusz Witkowski ◽  
Paweł Antczak ◽  
Arkadiusz Antczak

In this study we propose metaheuristic optimization algorithm, in which simulated annealing, multi agent approach with fuzzy logic are used. On the first level of solution search the multi agent approach is used, and on the second level – the simulated annealing. Two types of routing were considered: a serial and a parallel one. The multi-agent approach emphasizes flexibility rather than the optimality of solutions. On the other hand, search approaches such as simulated annealing, which focus more on the optimality of solutions.


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