Vascular Progenitor Cells in Chronic Obstructive Pulmonary Disease

2011 ◽  
Vol 8 (6) ◽  
pp. 528-534 ◽  
Author(s):  
J. A. Barbera ◽  
V. I. Peinado
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Progenitor Cells ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Vascular Progenitor Cells

scholarly journals Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

Stem Cells ◽  
2013 ◽  
Vol 31 (12) ◽  
pp. 2813-2826 ◽  
Author(s):  
Koralia E. Paschalaki ◽  
Richard D. Starke ◽  
Yanhua Hu ◽  
Nicolas Mercado ◽  
Andriana Margariti ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Dna Damage ◽  
Progenitor Cells ◽  
Pulmonary Disease ◽  
Endothelial Progenitor Cells ◽  
Chronic Obstructive ◽  
Endothelial Progenitor ◽  
Obstructive Pulmonary Disease

scholarly journals Endothelial progenitor cells in patients with chronic obstructive pulmonary disease

2013 ◽  
Vol 305 (12) ◽  
pp. L964-L969 ◽  
Author(s):  
Mairi Brittan ◽  
Mathilde M. Hoogenboom ◽  
Gareth J. Padfield ◽  
Olga Tura ◽  
Takeshi Fujisawa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Progenitor Cells ◽  
Pulmonary Disease ◽  
Endothelial Progenitor Cells ◽  
Mononuclear Cells ◽  
Chronic Obstructive ◽  
Endothelial Progenitor ◽  
Obstructive Pulmonary Disease ◽  
Circulating Endothelial Progenitor Cells ◽  
Colony Forming Units

The pathogenesis of chronic obstructive pulmonary disease is not fully understood. The objective of this study was to compare circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease to age, sex, and cigarette smoking matched healthy controls. Patients with chronic obstructive pulmonary disease ( n = 37) and healthy controls ( n = 19) were matched by age, sex, and smoking status. Circulating hematopoietic progenitor cells (CD34+ or CD133+ mononuclear cells) and endothelial progenitor cells (CD34+KDR+ or CD34+CD133+KDR+ mononuclear cells) were quantified by flow cytometry. Endothelial cell-colony forming units from peripheral blood mononuclear cells were quantified in vitro and phenotypic analysis carried out using immunocytochemistry. Patients with chronic obstructive pulmonary disease had more circulating mononuclear cells compared with controls (8.4 ± 0.6 vs. 5.9 ± 0.4 × 109 cells/l; P = 0.02). CD34+ hematopoietic progenitor cells were reduced as a proportion of mononuclear cells in patients compared with controls (0.99 ± 0.12 vs. 1.9 ± 0.12%; P = 0.02); however, there were no differences in the absolute number of CD34+, CD34+KDR+, or CD34+CD133+KDR+ cells ( P > 0.05 for all). Endothelial cell-colony forming units were increased in patients with chronic obstructive pulmonary disease compared with controls (13.7 ± 5.2 vs. 2.7 ± 0.9 colonies; P = 0.048). In contrast to previous studies, the number of circulating progenitor cells was not reduced in patients with chronic obstructive pulmonary disease compared with carefully matched controls. It seems unlikely that circulating endothelial progenitor cells or failure of angiogenesis plays a central role in the development of emphysema.

scholarly journals Circulating Progenitor Cells and Vascular Dysfunction in Chronic Obstructive Pulmonary Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e106163 ◽  
Author(s):  
Sandra Pizarro ◽  
Jéssica García-Lucio ◽  
Víctor I. Peinado ◽  
Olga Tura-Ceide ◽  
Marta Díez ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Progenitor Cells ◽  
Pulmonary Disease ◽  
Vascular Dysfunction ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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