AbstractThe one-pot synthesis of pyrido[2,3-d]
pyrimidine derivatives has been reported via
Knoevenagel-Michal addition pathways using substituted
aromatic aldehydes, Cyanoacetamide and 6-aminouracil
in N,N-dimethylformamide (DMF) solvent, with
4-dimethylaminopyridine (DMAP) as new organo catalyst
catalyst under ultrasonic irradiation. The results showed
that a series of aromatic aldehydes were effectively used to
prepare the targeted pyrido [2, 3-d] pyrimidine derivatives
with good to excellent yields (81-93 %) with no major effect
on the yield of product by electron donating/withdrawing
substituents. Short reaction time, environment friendly
procedure, excellent yields, inexpensive and readily
available catalyst are the advantages of this procedure.
All synthesized compounds were characterized by IR,
1HNMR, 13CNMR and mass spectral data.
Retraction. One-pot synthesis of new Pyrido [2,3-d] Pyrimidine derivatives under ultrasonic irradiation using organo catalyst 4-Dimethylaminopyridine (DMAP)
