scholarly journals One-pot synthesis of new Pyrido [2,3-d] Pyrimidine derivatives under ultrasonic irradiation using organo catalyst 4-Dimethylaminopyridine (DMAP)

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Imtiyaz Rasool Parrey ◽  
Athar Adil Hashmi
Keyword(s):  
Ultrasonic Irradiation ◽  
Aromatic Aldehydes ◽  
Major Effect ◽  
Mass Spectral Data ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Environment Friendly ◽  
Mass Spectral ◽  
One Pot Synthesis ◽  
The One

AbstractThe one-pot synthesis of pyrido[2,3-d] pyrimidine derivatives has been reported via Knoevenagel-Michal addition pathways using substituted aromatic aldehydes, Cyanoacetamide and 6-aminouracil in N,N-dimethylformamide (DMF) solvent, with 4-dimethylaminopyridine (DMAP) as new organo catalyst catalyst under ultrasonic irradiation. The results showed that a series of aromatic aldehydes were effectively used to prepare the targeted pyrido [2, 3-d] pyrimidine derivatives with good to excellent yields (81-93 %) with no major effect on the yield of product by electron donating/withdrawing substituents. Short reaction time, environment friendly procedure, excellent yields, inexpensive and readily available catalyst are the advantages of this procedure. All synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectral data.

scholarly journals A Facile Synthesis and Biological Screening of Pyrimidine Derivatives under Ultrasonic Irradiations by ZnCr2O4 Nano-Particles Catalyst

2021 ◽  
Vol 11 (1) ◽  
pp. 2996-3005
Keyword(s):  
Biological Activities ◽  
Aromatic Aldehydes ◽  
Vital Role ◽  
Nano Particles ◽  
Facile Synthesis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Biological Screening ◽  
Characterization Methods ◽  
The One

Using a recyclable catalyst, facile synthesis of pyrimidine derivatives (4a-e) is attributed through the one-pot multi-component reaction of 2-amino benzimidazole (1) substituted aromatic aldehydes (2a-e) with malononitrile (3) under ultrasonic irradiations. Synthesized derivatives might help society in getting more active pharmaceutical constituents. In this present work, series of substituted pyrimidine (4a-e) were synthesized and confirmed with different spectra characterization methods. The ZnCr2O4 nano-particles play a vital role in eco-friendly, highly efficient, recyclable heterogeneous nanocatalyst. Furthermore, synthesized pyrimidine derivatives showed significant biological activities. Advantages of this handy route are less reaction time, simple isolation, and highly yielded products.

scholarly journals AN EFFICIENT THREE COMPONENT ONE-POT SYNTHESIS OF -1,2,3,4-TETRAHYDRO-4-OXO- 6-(5-SUBSTITUTED 2-PHENYL-1H-INDOL-3-YL)-2-THIOXOPYRIMIDINE-5-CARBONITRILE AS ANTIMICROBIAL AND ANTITUBERCULAR AGENTS

2021 ◽  
pp. 94-97
Author(s):  
PRABHAKER WALMIK
Keyword(s):  
Spectral Data ◽  
13C Nmr ◽  
Antitubercular Agents ◽  
Mass Spectral Data ◽  
One Pot ◽  
1H And 13C Nmr ◽  
Spectral Techniques ◽  
Mass Spectral ◽  
One Pot Synthesis

Objective: The objective of the study was to synthesis of 1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1H-indol-3-yl)-2-thioxopyrimidine-5- carbonitrile derivatives (4a-c). Methods: The structures of all these unknown compounds have been confirmed with the help of physical and spectral techniques such as IR, 1H, and 13C NMR and mass spectral data and these newly synthesized compounds were evaluated for in-vitro antimicrobial and antitubercular activities. Results: Screening studies have demonstrated that the newly synthesized compound 4a exhibited promising antimicrobial and antitubercular properties. Conclusion: The final results revealed that compound 4a exhibited promising antimicrobial and antitubercular properties when compared to the standard drugs.

scholarly journals Cu-metal organic frameworks (Cu-MOF) as an environment-friendly and economical catalyst for one pot synthesis of tacrine derivatives

RSC Advances ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 1995-2003 ◽  
Author(s):  
Hoda Mollabagher ◽  
Salman Taheri ◽  
Mohammad majid Mojtahedi ◽  
SeyedAmirhossein Seyedmousavi
Keyword(s):  
Catalytic Activity ◽  
Metal Organic Frameworks ◽  
One Pot ◽  
Environment Friendly ◽  
One Pot Synthesis ◽  
Metal Organic ◽  
The One

The present work describes the catalytic activity of Cu-MOF for the one-pot synthesis of tacrine derivatives via a four-component reaction of 2-hydroxynaphthalene-1,4-dione, aldehydes, malononitrile and cycloketones in the presence of AlCl3.

Heterogeneous recyclable nano-CeO2 catalyst: efficient and eco-friendly synthesis of novel fused triazolo and tetrazolo pyrimidine derivatives in aqueous medium

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68788-68797 ◽  
Author(s):  
Lingala Suresh ◽  
P. Sagar Vijay Kumar ◽  
T. Vinodkumar ◽  
G. V. P. Chandramouli
Keyword(s):  
Aqueous Medium ◽  
Condensation Reaction ◽  
Bond Formation ◽  
Aromatic Aldehydes ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Multicomponent Condensation ◽  
The One

A ceria nanocatalyst was used for the one-pot, multicomponent condensation reaction of benzoylacetonitrile, aromatic aldehydes and 5-amino-triazole/tetrazole proceeding via C–C and C–N bond formation to deliver triazolo/tetrazolo[1,5-a]pyrimidines.

DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines

2017 ◽  
Vol 72 (5) ◽  
pp. 361-368 ◽  
Author(s):  
Esma Lamera ◽  
Sofiane Bouacida ◽  
Hocine Merazig ◽  
Aissa Chibani ◽  
Marc Le Borgne ◽  
...  
Keyword(s):  
Environmental Pollution ◽  
Efficient Method ◽  
Toxic Metals ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
Efficient Catalyst ◽  
One Pot Synthesis ◽  
The One ◽  
The Cost ◽  
Work Up

AbstractA new, convenient, and efficient method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is developed starting from phthalhydrazide, aromatic aldehydes, and malononitrile using 4-N,N-dimethylaminopyridin as catalyst. This modified route provides much higher yields and a simple work-up procedure of products. Also this methodology is of interest due to the use of ethanol as a solvent without use of any toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution.

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