Rare case of multiple meningiomas in nonneurofibromatosis patient at unusual locations

2017 ◽  
Vol 31 (2) ◽  
pp. 240-243 ◽  
Author(s):  
Vikrant Setia ◽  
Deepashu Sachdeva ◽  
Shrinivas Odugoudar ◽  
Pravin Borde ◽  
Daljit Singh
Keyword(s):  
Posterior Fossa ◽  
Rare Case ◽  
Intracranial Lesion ◽  
Multiple Meningiomas ◽  
Intraventricular Meningioma ◽  
Intracranial Lesions ◽  
Multiple Meningioma

Abstract Multiple meningioma is a condition in which more than one intracranial lesion is seen in different location and these lesions may occur with or without signs of neurofibromatosis. Incidence of multiple meningioma range from 1 to 10% in different series. We report a case of multiple meningioma in a 33 years old female who had 14 intracranial lesions both supratentorially and infratentorially, and underwent surgery for large right lateral intraventricular meningioma. She had two meningiomas located in posterior fossa associated with supratentorial meningioma, which has been rarely reported.

scholarly journals A rare case of multiple meningiomas with different histology

2017 ◽  
Vol 2 (2) ◽  
pp. 114-119
Author(s):  
Toma Papacocea ◽  
Andrei Mladin ◽  
Serban Papacocea
Keyword(s):  
Rare Case ◽  
Multiple Meningiomas

Multiple meningiomas in the posterior fossa

1985 ◽  
Vol 23 (4) ◽  
pp. 425-427 ◽  
Author(s):  
Takayuki Nagano ◽  
Iwao Saiki ◽  
Haruyuki Kanaya
Keyword(s):  
Posterior Fossa ◽  
Multiple Meningiomas

scholarly journals A rare case of post traumatic isolated bilateral abducens nerve palsy

2014 ◽  
Vol 21 (4) ◽  
pp. 497-499
Author(s):  
Manish Jaiswal ◽  
Saurabh Jain ◽  
Ashok Gandhi ◽  
Achal Sharma ◽  
R.S. Mittal
Keyword(s):  
Rare Case ◽  
Nerve Palsy ◽  
Abducens Nerve ◽  
Abducens Nerve Palsy ◽  
Resonance Imaging ◽  
Intracranial Lesion ◽  
Mri Brain ◽  
Post Traumatic ◽  
Magnetic Resonance Imaging Mri ◽  
Bilateral Abducens

Abstract Although unilateral abducens nerve palsy has been reported to be as high as 1% to 2.7% of traumatic brain injury, bilateral abducens nerve palsy following injury is extremely rare. In this report, we present the case of a patient who developed isolated bilateral abducens nerve palsy following minor head injury. He had a Glasgow Coma Score (GCS) of 15 points. Computed tomography (CT) images & Magnetic Resonance Imaging (MRI) brain demonstrated no intracranial lesion. Herein, we discuss the possible mechanisms of bilateral abducens nerve palsy and its management.

scholarly journals Multiple Meningiomas of the Spinal Canal and Posterior Fossa

1989 ◽  
Vol 29 (9) ◽  
pp. 834-837 ◽  
Author(s):  
Katsuhiro YAMASHITA ◽  
Tatsuo AKIMURA ◽  
Katsunori KAWANO ◽  
Naoto ADACHI ◽  
Tsutomu NAGAMITSU ◽  
...  
Keyword(s):  
Posterior Fossa ◽  
Spinal Canal ◽  
Multiple Meningiomas

Evidence for clonal spread in the development of multiple meningiomas

1995 ◽  
Vol 83 (4) ◽  
pp. 705-709 ◽  
Author(s):  
Jeffrey J. Larson ◽  
John M. Tew ◽  
Matthias Simon ◽  
Anil G. Menon
Keyword(s):  
X Chromosome ◽  
Progenitor Cell ◽  
Underlying Mechanism ◽  
X Chromosome Inactivation ◽  
Chromosome Inactivation ◽  
Content Type ◽  
Multiple Meningiomas ◽  
Multiple Meningioma ◽  
Polymerase Chain ◽  
Clonal Spread

✓ Meningiomas are common intracranial tumors that arise from the arachnoid cells of the meninges. Occasionally patients develop multiple meningiomas. Because the underlying mechanism of multiple meningioma formation is unknown, the authors examined the pattern of X chromosome inactivation in multiple meningiomas. Fifteen intracranial meningiomas were resected in four patients with multiple meningiomas to determine whether the tumors in patients with multiple meningiomas originate from a common progenitor cell or arise independently. Specimens were examined using polymerase chain reaction assays to detect the pattern of X chromosome inactivation. In each patient, all tumors showed inactivation of the same X chromosome, suggesting that tumors arose from the same clone of cells (p <0.0005). The authors conclude that multiple meningiomas arise from the uncontrolled spread of a single progenitor cell.

scholarly journals Primary pediatric cerebellar gliosarcoma

2020 ◽  
Vol 11 ◽  
pp. 96
Author(s):  
Syed Sarmad Bukhari ◽  
Muhammad Junaid ◽  
Ali Afzal ◽  
Anisa Kulsoom
Keyword(s):  
Magnetic Resonance ◽  
Posterior Fossa ◽  
Ventriculoperitoneal Shunt ◽  
Rare Case ◽  
Case Description ◽  
Magnetic Resonance Studies ◽  
Shunt Placement ◽  
Suboccipital Craniectomy ◽  
Posterior Fossa Lesion

Background: Primary gliosarcomas of the central nervous are rare and very few have been reported in the infratentorial compartment. Here, we describe such a lesion in a 12-year-old male. Case Description: A 12-year-old male presented with headache, ataxia, and vomiting. When Magnetic resonance studies documented a posterior fossa lesion, he underwent placement of a right ventriculoperitoneal shunt followed by a suboccipital craniectomy. The lesion proved to be a primary gliosarcoma. Unfortunately, it recurred 2 years later and required repeated resection. Conclusion: Here, we reviewed the rare case of a 12-year-old male requiring shunt placement and suboccipital craniectomy for a primary gliosarcoma that recurred 2 years later.

scholarly journals Nomegestrol Acetate or Chlormadinone Acetate Progestative Treatment in Women: Meningioma Behavior at Treatment Discontinuation

2021 ◽  
Author(s):  
Simona Mihaela Florea ◽  
Sebastien Boissonneau ◽  
Thibault Passeri ◽  
Anne Laure Bernat ◽  
Emmanuel Mandonnet ◽  
...  
Keyword(s):  
Treatment Discontinuation ◽  
Intracranial Meningioma ◽  
Close Monitoring ◽  
Chlormadinone Acetate ◽  
Multiple Meningiomas ◽  
Urgent Surgery ◽  
Nomegestrol Acetate ◽  
Multiple Meningioma ◽  
Stopping Treatment

Abstract Background: Associations between progestins and meningiomas is now well established. While the link between cyproterone acetate (CA) and meningioma was thoroughly studied, there is far less available data regarding the link between chlormadinone acetate (CHA) or nomegestrol acetate (NA) and risk of intracranial meningiomaMethods: We are presenting a series of 28 patients diagnosed with single or multiple meningiomas while treated with CHA-NA, in which the clinical and radiological course were analyzed after treatment discontinuation.Results: 28 women, with a mean age of 56 years old, were diagnosed with one or multiple meningioma while being treated with either CHA or NA. After stopping treatment, 89.3% showed either tumor shrinkage or tumor stabilization on follow-up MRIs. Multiple meningiomas were more likely observed in patients with long periods of treatment (>10 years, p 0.03) and seem to have a better clinical course (p 0.01). Most of the lesions were located on the skull base (55.4%). Four patients with multiple meningiomas showed discordant tumors evolution, with some tumors growing while others were decreasing. Most of the growing meningiomas were either convexity or midline lesions and more posteriorly located. Conclusion: Our study demonstrated a significant percentage of tumor diminution or stabilization after NA and CHA discontinuation. Therefore, treatment discontinuation with close monitoring should be the first measure taken if urgent surgery is not indicated. However, our results seem to be less encouraging than previously described in patients treated by CA, with more patients showing tumor growth despite treatment discontinuation. Further studies are needed to differentiate the effect of the different progestins treatment on meningiomas.

Rare case of closed depressed fracture of the posterior fossa in an adult causing brainstem dysfunction: Management dilemmas

2011 ◽  
Vol 59 (5) ◽  
pp. 778
Author(s):  
A Arivazhagan ◽  
DhananjayaI Bhat ◽  
R Bharath ◽  
Nupur Pruthi
Keyword(s):  
Posterior Fossa ◽  
Rare Case ◽  
Depressed Fracture ◽  
Brainstem Dysfunction

EPCO-29. GENOMIC PROFILING OF SPORADIC MULTIPLE MENINGIOMAS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi8-vi8
Author(s):  
Zeynep Erson-Omay ◽  
Tanyeri Barak ◽  
Shaurey Vetsa ◽  
Arushii Nadar ◽  
Danielle Miyagishima ◽  
...  
Keyword(s):  
Underlying Mechanism ◽  
Copy Number Variations ◽  
Genomic Profiling ◽  
Multiple Meningiomas ◽  
Whole Exome ◽  
Radiation History ◽  
History Of ◽  
Multiple Meningioma ◽  
Genomic Characterization

Abstract INTRODUCTION In rare cases, sporadic meningiomas can occur as multiple tumors in the same patient without a known germline mutation. While the underlying mechanism that leads to the formation of these multiple lesions has been hypothesized to be monoclonal or independent, the genomic profiles to support these theories remain understudied. METHODS Patients with an absence of family history of meningioma and prior radiation history with multiple metachronous meningiomas were included. All tissue underwent whole exome sequencing and analysis of somatic single nucleotide variations (SNV), small insertion/deletion (INDEL) events together with copy number variations (CNV) was performed. The genomic findings were correlated with clinical data. RESULTS A cohort of 13 meningiomas and one dural specimen, from five individuals was studied. The majority (9/13 tumors) of tumors had NF2 mutation/Chr22 loss. Four out of 5 cases had a monoclonal origination, whereas one case displayed an independent clonal formation. The somatic profile of dura was unrevealing. In contrast to the current understanding, we found monoclonal formation of multiple meningiomas is not exclusive to NF2 driven cases, as non-NF2 mutated meningiomas can too display a monoclonal etiology. Moreover, multiple monoclonal-originating lesions did not always display a homogenous profile, but rather exhibited heterogeneity through branching evolution, where some lesions acquired genomic alterations associated with aggressive behavior. The histological characterization of multiple meningioma cases does not necessarily overlap with the genomic clustering. CONCLUSION To our knowledge, this is the first study to use unbiased comprehensive genomic methods to reveal the heterogeneity of multiple meningioma genomic profiles. Our extensive genomic characterization of this cohort revealed that monoclonal formation can be observed both in NF2 and non-NF2 mutant meningiomas and can introduce heterogeneity. Therefore, in order to understand the full scope of each individual’s disease, detailed genomic profiling of all lesions, when possible, should be performed.

Cerebellar Agenesis: A Case to Remember

2019 ◽  
Vol 18 (01) ◽  
pp. 045-048
Author(s):  
John V. Dennison ◽  
Dharmesh R. Tailor
Keyword(s):  
Posterior Fossa ◽  
Congenital Anomalies ◽  
Rare Case ◽  
Genetic Causes ◽  
Cerebellar Function ◽  
Dandy Walker Malformation ◽  
Wide Range ◽  
Walker Malformation

AbstractThere is a wide range of congenital anomalies of the posterior fossa. Of these, absence of cerebellar components seems to exist on a spectrum, much like anomalies seen with the more frequently encountered Dandy–Walker malformation. Here, we present a rare case of cerebellar agenesis, as seen at our institution, which falls on the extreme side of the spectrum. We also discuss normal and aberrant posterior fossa development, established or hypothesized genetic causes of such development, and implications on cerebellar function.

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