High-Gradient Magnetic Capture of Ferrofluids: Implications for Drug Targeting and Tumor Embolization

2001 ◽  
Vol 56 (9-10) ◽  
pp. 909-911 ◽  
Author(s):  
Melánia Babincová ◽  
Peter Babinec ◽  
Christian Bergemann
Keyword(s):  
Magnetic Field ◽  
Strong Magnetic Field ◽  
Drug Targeting ◽  
Permanent Magnets ◽  
Maximum Pressure ◽  
Magnetic Targeting ◽  
Biomedical Sciences ◽  
Magnetic Gradient ◽  
Tumor Embolization ◽  
Magnetic Capture

Abstract One of the perspective methods of cancer chemotherapy is magnetic targeting of drugs to tumors. This task is usually accomplished using small permanent magnets attached near the desired sites. In this study a new much more effective approach is proposed which is based on a strong magnetic gradient using a ferromagnetic wire placed in a strong magnetic field. Feasibility of this approach has been evaluated by the formation of ferrofluid seals and measurement of maximum pressure the formed seal can resists. Using this method it is possible to capture even superparamagnetic particles with nanos­ize dimensions, therefore the method may have an interesting applications in biomedical sciences.

scholarly journals Investigation of Particle Steering for Different Cylindrical Permanent Magnets in Magnetic Drug Targeting

2020 ◽  
Vol 2 (1) ◽  
pp. 24
Author(s):  
Angelika Thalmayer ◽  
Samuel Zeising ◽  
Georg Fischer ◽  
Jens Kirchner
Keyword(s):  
Magnetic Field ◽  
Drug Targeting ◽  
Gravitational Force ◽  
Permanent Magnets ◽  
Fluid Velocity ◽  
Flow Characteristics ◽  
Cancer Drug ◽  
Magnetic Drug Targeting ◽  
Fluid Velocities ◽  
Particle Propagation

Magnetic Drug Targeting is a promising cancer treatment that offers the possibility of increasing therapeutic efficiency while reducing the patient’s side-effects. Thereby, the cancer-drug is bounded to magnetic nanoparticles, which are injected into a vessel and guided through the cardiovascular system into the tumor by an external magnetic field. However, a successful navigation depends on several multiphysical parameters including the properties of the nanoparticles, the flow characteristics of blood, and the gradient of the applied magnetic field. To investigate their impact, the propagation of particle packets within a 45∘ bifurcation vessel was modeled in COMSOL Multiphysics®. Therefore, magnets with varying radius-to-length ratios and magnetizations (radial and axial) were placed right before the bifurcation. Furthermore, different fluid velocities in addition to the influence of the gravitational force were evaluated. Overall, a strong dependency of the particle steering on the fluid velocity and the magnet’s radius-to-length ratio was observed. Moreover, a radial magnetization has a greater impact on the particle propagation, while the gravitation can be neglected for higher velocities. However, when a single permanent magnet is used, the results depict that it is a fine line between deflecting or trapping a particle at the vessel wall.

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