scholarly journals Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease

2018 ◽  
Vol 38 (19) ◽  
pp. 4556-4568 ◽  
Author(s):  
Doris D. Wang ◽  
Coralie de Hemptinne ◽  
Svjetlana Miocinovic ◽  
Jill L. Ostrem ◽  
Nicholas B. Galifianakis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Motor Cortex ◽  
Brain Stimulation ◽  
Primary Motor Cortex ◽  
Beta Oscillations ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Pallidal Deep Brain Stimulation and L-Dopa Effect on PET Motor Activation in Advanced Parkinson's Disease

2009 ◽  
Vol 19 (3) ◽  
pp. 253-258 ◽  
Author(s):  
István Valálik ◽  
Miklós Emri ◽  
Zsolt Lengyel ◽  
Pál Mikecz ◽  
Lajos Trón ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Advanced Parkinson’S Disease ◽  
Motor Activation ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Pallidal Deep Brain Stimulation Improves Higher Control of the Oculomotor System in Parkinson's Disease

2015 ◽  
Vol 35 (38) ◽  
pp. 13043-13052 ◽  
Author(s):  
C. A. Antoniades ◽  
P. Rebelo ◽  
C. Kennard ◽  
T. Z. Aziz ◽  
A. L. Green ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Oculomotor System ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

The effects of levodopa and ongoing deep brain stimulation on subthalamic beta oscillations in Parkinson's disease

2010 ◽  
Vol 226 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Gaia Giannicola ◽  
Sara Marceglia ◽  
Lorenzo Rossi ◽  
Simona Mrakic-Sposta ◽  
Paolo Rampini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Beta Oscillations ◽  
Deep Brain

Pallidal deep brain stimulation and L-dopa do not improve qualitative aspects of skilled reaching in Parkinson's disease

2005 ◽  
Vol 160 (1) ◽  
pp. 188-194 ◽  
Author(s):  
Kyle G. Melvin ◽  
Jon Doan ◽  
Sergio M. Pellis ◽  
Lesley Brown ◽  
Ian Q. Whishaw ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Skilled Reaching ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Bilateral Subthalamic Deep Brain Stimulation after Bilateral Pallidal Deep Brain Stimulation for Parkinson’s Disease

2011 ◽  
Vol 89 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Milind Deogaonkar ◽  
Guillermo A. Monsalve ◽  
Jenera Scott ◽  
Anwar Ahmed ◽  
Ali Rezai
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks

2021 ◽  
Author(s):  
Elie M Adam ◽  
Emery N. Brown ◽  
Nancy Kopell ◽  
Michelle M McCarthy
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Gamma Oscillations ◽  
Medium Spiny Neuron ◽  
Beta Oscillations ◽  
Movement Disability ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is highly effective in alleviating movement disability in patients with Parkinson's disease (PD). However, its therapeutic mechanism of action is unknown. The healthy striatum exhibits rich dynamics resulting from an interaction of beta, gamma and theta oscillations. These rhythms are at the heart of selection, initiation and execution of motor programs, and their loss or exaggeration due to dopamine (DA) depletion in PD is a major source of the behavioral deficits observed in PD patients. Interrupting abnormal rhythms and restoring the interaction of rhythms as observed in the healthy striatum may then be instrumental in the therapeutic action of DBS. We develop a biophysical networked model of a BG pathway to study how abnormal beta oscillations can emerge throughout the BG in PD, and how DBS can restore normal beta, gamma and theta striatal rhythms. Our model incorporates STN projections to the striatum, long known but understudied, that were recently shown to preferentially target fast spiking interneurons (FSI) in the striatum. We find that DBS in STN is able to normalize striatal medium spiny neuron (MSN) activity by recruiting FSI dynamics, and restoring the inhibitory potency of FSIs observed in normal condition. We also find that DBS allows the re-expression of gamma and theta rhythms, thought to be dependent on high DA levels and thus lost in PD, through cortical noise control. Our study shows how BG connectivity can amplify beta oscillations, and delineates the role of DBS in disrupting beta oscillations and providing corrective input to STN efferents to restore healthy striatal dynamics. It also suggests how gamma oscillations can be leveraged to enhance or supplement DBS treatment and improve its effectiveness.

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