Crosstalk between α7 and α3β4 nicotinic receptors prevents their desensitization in human chromaffin cells

2021 ◽  
pp. JN-RM-1115-21
Author(s):  
Amanda Jiménez-Pompa ◽  
Sara Sanz-Lázaro ◽  
Romidan Ewere Omodolor ◽  
José Medina-Polo ◽  
Carmen González-Enguita ◽  
...  
Keyword(s):  
Chromaffin Cells ◽  
Nicotinic Receptors

scholarly journals Differential Expression of α-Bungarotoxin-Sensitive Neuronal Nicotinic Receptors in Adrenergic Chromaffin Cells: A Role for Transcription Factor Egr-1

1997 ◽  
Vol 17 (17) ◽  
pp. 6554-6564 ◽  
Author(s):  
Manuel Criado ◽  
Eduardo Domı́nguez del Toro ◽  
Carmen Carrasco-Serrano ◽  
Frazer I. Smillie ◽  
José M. Juı́z ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Differential Expression ◽  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Neuronal Nicotinic Receptors

scholarly journals Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells

FEBS Letters ◽  
1997 ◽  
Vol 418 (1-2) ◽  
pp. 39-42 ◽  
Author(s):  
Victor Izaguirre ◽  
José M Fernández-Fernández ◽  
Valentı́n Ceña ◽  
Carmen González-Garcı́a
Keyword(s):  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Tricyclic Antidepressants ◽  
Atp Secretion ◽  
Bovine Chromaffin Cells

scholarly journals Native α6β4∗ nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland

2011 ◽  
Vol 26 (1) ◽  
pp. 346-354 ◽  
Author(s):  
Alberto Pérez‐Alvarez ◽  
Alicia Hernández‐Vivanco ◽  
J. Michael McIntosh ◽  
Almudena Albillos
Keyword(s):  
Adrenal Gland ◽  
Chromaffin Cells ◽  
Nicotinic Receptors

Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine

2006 ◽  
Vol 535 (1-3) ◽  
pp. 13-24 ◽  
Author(s):  
Juana Ma González-Rubio ◽  
Antonio M. García de Diego ◽  
Javier Egea ◽  
Román Olivares ◽  
Jonathan Rojo ◽  
...  
Keyword(s):  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Adrenal Chromaffin Cells ◽  
Adrenal Chromaffin

scholarly journals Antagonism of nicotinic receptors of rat chromaffin cells by N,N,N-trimethyl-1-(4-trans -stilbenoxy)-2-propylammonium iodide: a patch clamp and ligand binding study

2000 ◽  
Vol 129 (8) ◽  
pp. 1771-1779 ◽  
Author(s):  
Silvia Di Angelantonio ◽  
Andrea Nistri ◽  
Milena Moretti ◽  
Francesco Clementi ◽  
Cecilia Gotti
Keyword(s):  
Patch Clamp ◽  
Ligand Binding ◽  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Binding Study

scholarly journals Full activation of an α7-α3β4 nicotinic receptor complex avoids receptor desensitization in human chromaffin cells

2020 ◽  
Author(s):  
Amanda Jiménez-Pompa ◽  
Sara Sanz-Lázaro ◽  
José Medina-Polo ◽  
Carmen González-Enguita ◽  
Jesús Blázquez ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Adrenal Glands ◽  
Gradual Increase ◽  
Receptor Complex ◽  
Receptor Desensitization ◽  
Partial Activation ◽  
Full Activation

Abstractα7 nicotinic receptors have been involved in numerous pathologies. A hallmark of these receptors is their extremely fast desensitization, a process not fully understood yet. Here we show that human native α7 and α3β4 nicotinic receptors physically interact in human chromaffin cells of adrenal glands. The full activation of this α7-α3β4 receptor complex avoids subtypes receptor desensitization, leading to gradual increase of currents with successive acetylcholine pulses. Instead, full and partial activation with choline of α7 and α3β4 subtypes, respectively, of this linked receptor leads to α7 receptor desensitization. Therefore choline, a product of the acetylcholine hydrolysis, acts as a brake by limiting the increase of currents by acetylcholine. Very importantly, the efficiency of the α7-α3β4 interaction diminishes in subjets older than 50 years, accordingly increasing receptor desensitization and decreasing nicotinic currents. These results open a new line of research to achieve improved therapeutic treatments for nicotinic receptors related diseases.

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