scholarly journals Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

2009 ◽  
Vol 29 (39) ◽  
pp. 12045-12058 ◽  
Author(s):  
H. Yuan ◽  
K. B. Hansen ◽  
K. M. Vance ◽  
K. K. Ogden ◽  
S. F. Traynelis
Keyword(s):  
Nmda Receptor ◽  
Receptor Function ◽  
Amino Terminal ◽  
Terminal Domain ◽  
Nmda Receptor Function ◽  
Amino Terminal Domain

scholarly journals Anti-NMDAR encephalitis induced in mice by active immunization with peptides of the amino-terminal domain of the GluN1 subunit

2020 ◽  
Author(s):  
Yuewen Ding ◽  
Zheye Zhou ◽  
Jinyu Chen ◽  
Yu Peng ◽  
Haitao Wang ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptors ◽  
Ectopic Expression ◽  
Active Immunization ◽  
Autoimmune Response ◽  
Ovarian Teratoma ◽  
Amino Terminal ◽  
Terminal Domain ◽  
Nmda Receptor Encephalitis ◽  
Amino Terminal Domain

Abstract Anti-N-methyl-D-aspartate receptor (NMDA) receptor encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesias, and seizures. Ectopic expression of NMDA receptors associated with ovarian teratoma is thought to mediate the initial autoimmune response against NMDA receptor encephalitis. Due to the lack of suitable animal models, the underlying mechanism of the disease remains unclear. This study described a new mice model of active immunization against the NMDA receptor with amino-terminal domain (ATD) peptides. After 12 weeks of immunization, mice were showed significant behavioral disorders and memory loss. Antibodies from CSF of immunized mice decreased surface NMDAR cluster density on hippocampus neurons. It also impaired the LTP induced at the Schaffer collateral to CA1 synapse and reduced NMDA receptors-induced calcium influx. The new model may help further research into the pathogenesis of the disease and the development of potential new therapies.

scholarly journals Thermodynamics of the NMDA Receptor Amino-Terminal Domain

2019 ◽  
Vol 116 (3) ◽  
pp. 400a
Author(s):  
Remy A. Yovanno ◽  
Albert Y. Lau
Keyword(s):  
Nmda Receptor ◽  
Amino Terminal ◽  
Terminal Domain ◽  
Amino Terminal Domain

scholarly journals Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

2009 ◽  
Vol 28 (24) ◽  
pp. 3910-3920 ◽  
Author(s):  
Erkan Karakas ◽  
Noriko Simorowski ◽  
Hiro Furukawa
Keyword(s):  
Nmda Receptor ◽  
Nr2b Subunit ◽  
Amino Terminal ◽  
Terminal Domain ◽  
Amino Terminal Domain
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