scholarly journals Reducing Agents Sensitize C-Type Nociceptors by Relieving High-Affinity Zinc Inhibition of T-Type Calcium Channels

2007 ◽  
Vol 27 (31) ◽  
pp. 8250-8260 ◽  
Author(s):  
M. T. Nelson ◽  
J. Woo ◽  
H.-W. Kang ◽  
I. Vitko ◽  
P. Q. Barrett ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Reducing Agents ◽  
High Affinity ◽  
Zinc Inhibition

scholarly journals High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

1997 ◽  
Vol 17 (15) ◽  
pp. 5711-5725 ◽  
Author(s):  
Pierre Paoletti ◽  
Philippe Ascher ◽  
Jacques Neyton
Keyword(s):  
High Affinity ◽  
Zinc Inhibition

scholarly journals Silver staining of the nucleolus organizer regions (NOR) requires clusters of sulfhydryl groups.

1982 ◽  
Vol 30 (9) ◽  
pp. 908-911 ◽  
Author(s):  
A De Capoa ◽  
M Ferraro ◽  
P Lavia ◽  
F Pelliccia ◽  
A Finazzi-Agrò
Keyword(s):  
Heavy Metals ◽  
Silver Staining ◽  
Reducing Agents ◽  
Nucleolus Organizer ◽  
The Other ◽  
Nuclear Proteins ◽  
Staining Reaction ◽  
Nucleolus Organizer Regions ◽  
High Affinity ◽  
Per Se

Silver stainability of nucleolus organizer regions (NORs) appears to be correlated with the presence of grouped sulfhydryl (SH) side chains of proteins. In fact, heavy metals with high affinity for SH groups, such as Hg and Cu, do prevent the silver staining reaction. Ferricyanide, which is known to oxidize SH to disulfides, also prevents any further reaction with silver. On the other hand, alkali and reducing agents (mercaptoethanol, cyanide) do not affect silver stainability of the NORs. These results show that the silver staining reaction is not related to disulfide or persulfide groups and that alkali-soluble, acidic nuclear proteins per se do not play a major role in this process.

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