scholarly journals Chemical Stimulation of the Ventral Hippocampus Elevates Nucleus Accumbens Dopamine by Activating Dopaminergic Neurons of the Ventral Tegmental Area

2000 ◽  
Vol 20 (4) ◽  
pp. 1635-1642 ◽  
Author(s):  
Mark Legault ◽  
Pierre-Paul Rompré ◽  
Roy A. Wise
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Dopaminergic Neurons ◽  
Ventral Hippocampus ◽  
Chemical Stimulation ◽  
Ventral Tegmental ◽  
Stimulation Of

Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus

2003 ◽  
Vol 368 (4) ◽  
pp. 324-327 ◽  
Author(s):  
M. J. Cano-Cebri�n ◽  
T. Zornoza-Sabina ◽  
C. Guerri ◽  
A. Polache ◽  
L. Granero
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Hippocampus ◽  
Chemical Stimulation ◽  
Stimulation Of

Cardiovascular depressor responses to stimulation of substantia nigra and ventral tegmental area

1997 ◽  
Vol 273 (6) ◽  
pp. H2549-H2557 ◽  
Author(s):  
Gilbert J. Kirouac ◽  
John Ciriello
Keyword(s):  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Intravenous Administration ◽  
Dopaminergic Neurons ◽  
Cardiovascular Responses ◽  
Receptor Blocker ◽  
Transitional Region ◽  
Pars Lateralis ◽  
Ventral Tegmental ◽  
Stimulation Of

Experiments were done in α-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect ofl-glutamate (Glu) stimulation of the substantia nigra (SN) and ventral tegmental area (VTA) on arterial pressure (AP) and heart rate (HR). Glu stimulation of the SN pars compacta (SNC) elicited decreases in both mean AP (MAP; −18.9 ± 1.3 mmHg; n = 52) and HR (−26.1 ± 1.6 beats/min; n = 46) at 81% of the sites stimulated. On the other hand, stimulation of the SN pars lateralis or pars reticulata did not elicit cardiovascular responses. Stimulation of the adjacent VTA region elicited similar decreases in MAP (−18.0 ± 2.6 mmHg; n = 20) and HR (−25.4 ± 3.8 beats/min; n = 17) at ∼74% of the sites stimulated. Intravenous administration of the dopamine D2-receptor antagonist raclopride significantly attenuated both the MAP (70%) and the HR (54%) responses elicited by stimulation of the transitional region where the SNC merges with the lateral VTA (SNC-VTA region). Intravenous administration of the muscarinic receptor blocker atropine methyl bromide had no effect on the magnitude of the MAP and HR responses to stimulation of the SNC-VTA region, whereas administration of the nicotinic receptor blocker hexamethonium bromide significantly attenuated both the depressor and the bradycardic responses. These data suggest that dopaminergic neurons in the SNC-VTA region activate a central pathway that exerts cardiovascular depressor effects that are mediated by the inhibition of sympathetic vasoconstrictor fibers to the vasculature and cardioacceleratory fibers to the heart.

Hippocampal dopamine receptors modulate cFos expression in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus

2005 ◽  
Vol 49 (7) ◽  
pp. 1067-1076 ◽  
Author(s):  
Teodoro Zornoza ◽  
María J. Cano-Cebrián ◽  
Fernando Martínez-García ◽  
Ana Polache ◽  
Luis Granero
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptors ◽  
Ventral Hippocampus ◽  
Chemical Stimulation ◽  
Rat Nucleus Accumbens ◽  
Stimulation Of
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