scholarly journals Identification of the Kainate Receptor Subunits Underlying Modulation of Excitatory Synaptic Transmission in the CA3 Region of the Hippocampus

2000 ◽  
Vol 20 (22) ◽  
pp. 8269-8278 ◽  
Author(s):  
Anis Contractor ◽  
Geoffrey T. Swanson ◽  
Andreas Sailer ◽  
Stephen O'Gorman ◽  
Stephen F. Heinemann
Keyword(s):  
Synaptic Transmission ◽  
Excitatory Synaptic Transmission ◽  
Kainate Receptor ◽  
Kainate Receptor Subunits ◽  
Ca3 Region

The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus

1998 ◽  
Vol 37 (10-11) ◽  
pp. 1269-1277 ◽  
Author(s):  
M Vignes ◽  
V.R.J Clarke ◽  
M.J Parry ◽  
D Bleakman ◽  
D Lodge ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Excitatory Synaptic Transmission ◽  
Rat Hippocampus ◽  
Kainate Receptor

Development of Excitatory Circuitry in the Hippocampus

1998 ◽  
Vol 79 (4) ◽  
pp. 2013-2024 ◽  
Author(s):  
Albert Y. Hsia ◽  
Robert C. Malenka ◽  
Roger A. Nicoll
Keyword(s):  
Synaptic Transmission ◽  
Action Potentials ◽  
Pyramidal Cells ◽  
Excitatory Synaptic Transmission ◽  
Developmental Strategy ◽  
Excitatory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Quantal Size ◽  
Physiological Approach ◽  
Local Circuitry

Hsia, Albert Y., Robert C. Malenka, and Roger A. Nicoll. Development of excitatory circuitry in the hippocampus. J. Neurophysiol. 79: 2013–2024, 1998. Assessing the development of local circuitry in the hippocampus has relied primarily on anatomic studies. Here we take a physiological approach, to directly evaluate the means by which the mature state of connectivity between CA3 and CA1 hippocampal pyramidal cells is established. Using a technique of comparing miniature excitatory postsynaptic currents (mEPSCs) to EPSCs in response to spontaneously occurring action potentials in CA3 cells, we found that from neonatal to adult ages, functional synapses are created and serve to increase the degree of connectivity between CA3-CA1 cell pairs. Neither the probability of release nor mean quantal size was found to change significantly with age. However, the variability of quantal events decreases substantially as synapses mature. Thus in the hippocampus the developmental strategy for enhancing excitatory synaptic transmission does not appear to involve an increase in the efficacy at individual synapses, but rather an increase in the connectivity between cell pairs.

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