scholarly journals Absence of Whisker-Related Pattern Formation in Mice with NMDA Receptors Lacking Coincidence Detection Properties and Calcium Signaling

2003 ◽  
Vol 23 (6) ◽  
pp. 2323-2332 ◽  
Author(s):  
York Rudhard ◽  
Matthias Kneussel ◽  
Mohammed A. Nassar ◽  
Georg F. Rast ◽  
Alexander J. Annala ◽  
...  
Keyword(s):  
Pattern Formation ◽  
Nmda Receptors ◽  
Calcium Signaling ◽  
Coincidence Detection ◽  
Related Pattern

scholarly journals Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ilaria Bertocchi ◽  
Ahmed Eltokhi ◽  
Andrey Rozov ◽  
Vivan Nguyễn Chi ◽  
Vidar Jensen ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Nmda Receptor ◽  
Nmda Receptors ◽  
Focal Epilepsy ◽  
Mechanistic Explanation ◽  
Audiogenic Seizures ◽  
Coincidence Detection ◽  
Oscillatory Activity ◽  
Sensory Stimuli ◽  
Inherent Voltage

AbstractThe NMDA receptor-mediated Ca2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations of this coincidence detection provoked complex clinical phenotypes, ranging from reduced muscle strength to epileptic seizures and intellectual disability. By using our gene-targeted mouse line (Grin2aN615S), we show that voltage-independent glutamate-gated signaling of GluN2A-containing NMDA receptors is associated with NMDAR-dependent audiogenic seizures due to hyperexcitable midbrain circuits. In contrast, the NMDAR antagonist MK-801-induced c-Fos expression is reduced in the hippocampus. Likewise, the synchronization of theta- and gamma oscillatory activity is lowered during exploration, demonstrating reduced hippocampal activity. This is associated with exploratory hyperactivity and aberrantly increased and dysregulated levels of attention that can interfere with associative learning, in particular when relevant cues and reward outcomes are disconnected in space and time. Together, our findings provide (i) experimental evidence that the inherent voltage-dependent Ca2+ signaling of NMDA receptors is essential for maintaining appropriate responses to sensory stimuli and (ii) a mechanistic explanation for the neurological manifestations seen in the NMDAR-related human disorders with GRIN2 variant-meidiated intellectual disability and focal epilepsy.

scholarly journals Fetal NGF augmentation preserves excess trigeminal ganglion cells and interrupts whisker-related pattern formation

1994 ◽  
Vol 14 (5) ◽  
pp. 3389-3403 ◽  
Author(s):  
TA Henderson ◽  
EM Johnson ◽  
PA Osborne ◽  
MF Jacquin
Keyword(s):  
Pattern Formation ◽  
Trigeminal Ganglion ◽  
Ganglion Cells ◽  
Related Pattern

scholarly journals Effect of neurosteroids on nitric oxide signaling and calcium signaling in CHO cells co-expressing NMDA receptors and nNOS

2001 ◽  
Vol 41 (supplement) ◽  
pp. S142
Author(s):  
K Shibuya ◽  
H Mukai ◽  
S Uchino ◽  
S Kominami ◽  
T Nagano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nmda Receptors ◽  
Calcium Signaling ◽  
Cho Cells ◽  
Nitric Oxide Signaling

scholarly journals Effect of neurosteroids on calcium signaling mediated by NMDA receptors

2000 ◽  
Vol 40 (supplement) ◽  
pp. S214
Author(s):  
H. Mukai ◽  
S. Uchino ◽  
K. Shibuya ◽  
S. Kawato
Keyword(s):  
Nmda Receptors ◽  
Calcium Signaling

Sigma, PCP, and NMDA Receptors: Research Monograph 133

1993 ◽  
Author(s):  
Errol B. De Souza ◽  
Doris Clouet ◽  
Edythe D. London
Keyword(s):  
Nmda Receptors

Timing by coincidence detection: What's all the noise about?

2012 ◽  
Author(s):  
Catalin V. Buhusi ◽  
Sorinel Oprisan
Keyword(s):  
Coincidence Detection
Sign in / Sign up

Export Citation Format

Share Document