Colchicine affects cell motility, pattern formation and stalk cell differentiation in Dictyostelium by altering calcium signaling

2012 ◽  
Vol 83 (4) ◽  
pp. 185-199 ◽  
Author(s):  
Yekaterina Poloz ◽  
Danton H. O'Day
Keyword(s):  
Cell Differentiation ◽  
Pattern Formation ◽  
Cell Motility ◽  
Calcium Signaling ◽  
Stalk Cell ◽  
Motility Pattern

scholarly journals Microbe Profile: Dictyostelium discoideum: model system for development, chemotaxis and biomedical research

Microbiology ◽  
2021 ◽  
Author(s):  
Catherine J. Pears ◽  
Julian D. Gross
Keyword(s):  
Pattern Formation ◽  
Cell Motility ◽  
Dictyostelium Discoideum ◽  
Biomedical Research ◽  
Model System ◽  
Developmental Pattern ◽  
Social Amoeba ◽  
The Social ◽  
Host Pathogen ◽  
Soil Amoeba

The social amoeba Dictyostelium discoideum is a versatile organism that is unusual in alternating between single-celled and multi-celled forms. It possesses highly-developed systems for cell motility and chemotaxis, phagocytosis, and developmental pattern formation. As a soil amoeba growing on microorganisms, it is exposed to many potential pathogens; it thus provides fruitful ways of investigating host-pathogen interactions and is emerging as an influential model for biomedical research.

scholarly journals Characterization of aDictyosteliumFactor That Acts Synergistically with DIF to Induce Terminal Stalk Cell Differentiation

1997 ◽  
Vol 184 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Yohko Yamada ◽  
Koji Okamoto ◽  
Jeffrey Williams
Keyword(s):  
Cell Differentiation ◽  
Stalk Cell

Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in Dictyostelium discoideum

FEBS Letters ◽  
1993 ◽  
Vol 322 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Yuzuru Kubohara ◽  
Koji Okamoto ◽  
Yoshimasa Tanaka ◽  
Ken-ichi Asahi ◽  
Akira Sakurai ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Dictyostelium Discoideum ◽  
Leukemic Cells ◽  
Stalk Cell

Cellulose microfibrils, cell motility, and plasma membrane protein organization change in parallel during culmination in Dictyostelium discoideum

1996 ◽  
Vol 109 (13) ◽  
pp. 3079-3087 ◽  
Author(s):  
M.J. Grimson ◽  
C.H. Haigler ◽  
R.L. Blanton
Keyword(s):  
Cell Motility ◽  
Dictyostelium Discoideum ◽  
Plasma Membranes ◽  
Freeze Fracture ◽  
Cellulose Microfibrils ◽  
Stalk Cell ◽  
Cellulose Synthesis ◽  
Particle Aggregates ◽  
Terminal Complexes

Prestalk cells of Dictyostelium discoideum contribute cellulose to two distinct structures, the stalk tube and the stalk cell wall, during culmination. This paper demonstrates by freeze fracture electron microscopy that two distinct types of intramembrane particle aggregates, which can be characterized as cellulose microfibril terminal complexes, occur in the plasma membranes of cells synthesizing these different forms of cellulose. The same terminal complexes were observed in situ in developing culminants and in vitro in monolayer cells induced to synthesize the two types of cellulose. We propose that cessation of cell motility is associated with a change in packing and intramembrane mobility of the particle aggregates, which cause a change in the nature of the cellulose synthesized. The terminal complexes are compared to those described in other organisms and related to the previous hypothesis of two modes of cellulose synthesis in Dictyostelium.

Ammonia depletion and DIF trigger stalk cell intact Dictyostelium discoideum slugs

Development ◽  
1989 ◽  
Vol 105 (3) ◽  
pp. 569-574 ◽  
Author(s):  
M. Wang ◽  
P. Schaap
Keyword(s):  
Cell Differentiation ◽  
Cyclic Amp ◽  
Dictyostelium Discoideum ◽  
Stalk Cell

The differentiation-inducing factor, DIF, was induce stalk cell differentiation in Dictyostelium incubated as submerged monolayers. We investigated the regulates the differentiation of stalk cells in the was found that in migrating or submerged slugs DIF cell differentiation, which is most likely due to the antagonist. Cyclic AMP and ammonia were earlier antagonists in vitro. We show here that ammonia, but an antagonist for DIF-induced stalk cell can induce stalk cell differentiation when ammonia are enzymically depleted. However, depletion of cAMP increase the efficacy of DIF. We propose that the cell differentiation during early culmination may be drop in ammonia levels inside the organism.

scholarly journals Absence of Whisker-Related Pattern Formation in Mice with NMDA Receptors Lacking Coincidence Detection Properties and Calcium Signaling

2003 ◽  
Vol 23 (6) ◽  
pp. 2323-2332 ◽  
Author(s):  
York Rudhard ◽  
Matthias Kneussel ◽  
Mohammed A. Nassar ◽  
Georg F. Rast ◽  
Alexander J. Annala ◽  
...  
Keyword(s):  
Pattern Formation ◽  
Nmda Receptors ◽  
Calcium Signaling ◽  
Coincidence Detection ◽  
Related Pattern

Cellular differentiation and pattern formation in the absence of morphogenesis in the cellular slime mould Polysphondylium pallidum: evidence for a biochemical tip (organizer) in submerged aggregates

1981 ◽  
Vol 27 (9) ◽  
pp. 924-936 ◽  
Author(s):  
Gary D. Paterno ◽  
Danton H. O'Day
Keyword(s):  
Cell Differentiation ◽  
Cellular Differentiation ◽  
Periodic Acid ◽  
Neutral Red ◽  
Stalk Cell ◽  
Periodic Acid Schiff ◽  
Slime Mould ◽  
Polysphondylium Pallidum ◽  
Cellular Slime ◽  
Roller Tube Culture

When amoebae of Polysphondylium pallidum WS320 are placed in nonnutrient buffer in roller tube culture they form spherical or ellipsoidal aggregates. At first the aggregates demonstrate a "loose" morphology but by 12 h, with the formation of a cellulose-containing, peripheral sheath, they become "tight" aggregates. At this time stalk differentiation begins. Using various methods for the resolution of prespore (ultrastructure, spore antigen immunofluorescence, periodic acid – Schiff staining) and prestalk (ultrastructure, alkaline phosphatase histochemistry, neutral red staining, Calcofluor fluorescence) cell localization, the pattern of cell differentiation in submerged aggregates was shown to be essentially identical to that of normal pseudoplasmodia. Furthermore, using a cAMP bioassay it was revealed that the submerged aggregates, while devoid of a morphological tip, do possess a biochemical tip which is correlated with sites of neutral red staining and stalk cell differentiation. As a result of these studies, an earlier argument that the tip of the pseudoplasmodium is not essential for the establishment of pattern or in the "organization" of cellular differentiation during slime mould development is contradicted.

Cell differentiation and pattern formation in the developing mammalian retina

1988 ◽  
Vol 8 ◽  
pp. S27-S41 ◽  
Author(s):  
Colin J. Barnstable ◽  
Andrew S. Blum ◽  
Stephen H. Devoto ◽  
David Hicks ◽  
Maria A. Morabito ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Pattern Formation ◽  
Mammalian Retina
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