scholarly journals Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

2005 ◽  
Vol 25 (44) ◽  
pp. 10262-10272 ◽  
Author(s):  
C. Culmsee
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Apoptosis Inducing Factor

scholarly journals BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

2001 ◽  
Vol 98 (26) ◽  
pp. 15318-15323 ◽  
Author(s):  
N. Plesnila ◽  
S. Zinkel ◽  
D. A. Le ◽  
S. Amin-Hanjani ◽  
Y. Wu ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation

Apoptosis inducing factor (AIF) is essential for neuronal cell death following transient focal cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S466-S466
Author(s):  
Carsten Culmsee ◽  
Changlian Zhu ◽  
Miriam Höhn ◽  
Stefan Landshamer ◽  
Uta Mamrak ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Transient Focal Cerebral Ischemia ◽  
Apoptosis Inducing Factor

scholarly journals Nuclear Translocation of Apoptosis-Inducing Factor after Focal Cerebral Ischemia

2004 ◽  
Vol 24 (4) ◽  
pp. 458-466 ◽  
Author(s):  
Nikolaus Plesnila ◽  
Changlian Zhu ◽  
Carsten Culmsee ◽  
Moritz Gröger ◽  
Michael A. Moskowitz ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Cytochrome C ◽  
Nuclear Translocation ◽  
Focal Cerebral Ischemia ◽  
Mitochondrial Protein ◽  
Neuronal Cell ◽  
Experimental Stroke ◽  
Cytochrome C Release ◽  
Apoptosis Inducing Factor

Signaling cascades associated with apoptosis contribute to cell death after focal cerebral ischemia. Cytochrome c release from mitochondria and the subsequent activation of caspases 9 and 3 are critical steps. Recently, a novel mitochondrial protein, apoptosis-inducing factor (AIF), has been implicated in caspase-independent programmed cell death following its translocation to the nucleus. We, therefore, addressed the question whether AIF also plays a role in cell death after focal cerebral ischemia. We detected AIF relocation from mitochondria to nucleus in primary cultured rat neurons 4 and 8 hours after 4 hours of oxygen/glucose deprivation. In ischemic mouse brain, AIF was detected within the nucleus 1 hour after reperfusion after 45 minutes occlusion of the middle cerebral artery. AIF translocation preceded cell death, occurred before or at the time when cytochrome c was released from mitochondria, and was evident within cells showing apoptosis-related DNA fragmentation. From these findings, we infer that AIF may be involved in neuronal cell death after focal cerebral ischemia and that caspase-independent signaling pathways downstream of mitochondria may play a role in apoptotic-like cell death after experimental stroke.

scholarly journals dl-3-n-Butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway

2010 ◽  
Vol 1359 ◽  
pp. 216-226 ◽  
Author(s):  
Jimei Li ◽  
Yin Li ◽  
Molly Ogle ◽  
Xin Zhou ◽  
Minke Song ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Jnk Pathway

Histone Deacetylase 6 Inhibition Attenuates Neuronal Cell Death after Oxygen-Glucose Deprivation and Reoxygenation

2016 ◽  
Vol 223 (4) ◽  
pp. S82 ◽  
Author(s):  
Vahagn C. Nikolian ◽  
Peter J. Bruhn ◽  
Patrick E. Georgoff ◽  
Ihab Halaweish ◽  
Baihong Pan ◽  
...  
Keyword(s):  
Cell Death ◽  
Histone Deacetylase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Histone Deacetylase 6

Characterization of neuronal cell death in normal and diabetic rats following exprimental focal cerebral ischemia

Life Sciences ◽  
2001 ◽  
Vol 69 (23) ◽  
pp. 2801-2810 ◽  
Author(s):  
Gui-Xia Wang ◽  
Guang-Ren Li ◽  
Ying-Di Wang ◽  
Tong-Shu Yang ◽  
Yi-Bing Ouyang
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Diabetic Rats
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