GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor  1M1- 2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site

M. Bali; M. Jansen; M. H. Akabas

doi:10.1523/jneurosci.6090-08.2009

GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor 1M1- 2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site

Journal of Neuroscience ◽

10.1523/jneurosci.6090-08.2009 ◽

2009 ◽

Vol 29 (10) ◽

pp. 3083-3092 ◽

Cited By ~ 53

Author(s):

M. Bali ◽

M. Jansen ◽

M. H. Akabas

Keyword(s):

Homology Modeling ◽

Binding Site ◽

Gabaa Receptor ◽

Experimental Basis ◽

Intravenous Anesthetic ◽

Subunit Interface

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Faculty Opinions recommendation of GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158333.618480 ◽

2009 ◽

Author(s):

Stuart Forman

Keyword(s):

Homology Modeling ◽

Binding Site ◽

Gabaa Receptor ◽

Experimental Basis ◽

Receptor Alpha ◽

Intravenous Anesthetic ◽

Subunit Interface

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Homology Modeling and Antagonist Binding Site Study of the Human Histamine H2 Receptor

Medicinal Chemistry ◽

10.2174/1573406411208061084 ◽

2012 ◽

Vol 8 (6) ◽

pp. 1084-1092 ◽

Cited By ~ 1

Author(s):

Jing Zhang ◽

Tao Qi ◽

Jing Wei

Keyword(s):

Homology Modeling ◽

Binding Site ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Antagonist Binding ◽

Human Histamine

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Linear and Nonlinear 3D-QSAR Approaches in Tandem with Ligand-Based Homology Modeling as a Computational Strategy To Depict the Pyrazolo-Triazolo-Pyrimidine Antagonists Binding Site of the Human Adenosine A2A Receptor

Journal of Chemical Information and Modeling ◽

10.1021/ci700300w ◽

2008 ◽

Vol 48 (2) ◽

pp. 350-363 ◽

Cited By ~ 18

Author(s):

Lisa Michielan ◽

Magdalena Bacilieri ◽

Andrea Schiesaro ◽

Chiara Bolcato ◽

Giorgia Pastorin ◽

...

Keyword(s):

Homology Modeling ◽

Binding Site ◽

3D Qsar ◽

Adenosine A2a Receptor ◽

A2a Receptor ◽

Linear And Nonlinear ◽

Adenosine A2a ◽

Computational Strategy

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Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABAA Receptor

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.105.084681 ◽

2005 ◽

Vol 314 (2) ◽

pp. 717-724 ◽

Cited By ~ 33

Author(s):

Barbara Langen ◽

Ute Egerland ◽

Katrin Bernöster ◽

Rita Dost ◽

Klaus Unverferth ◽

...

Keyword(s):

Binding Site ◽

Gabaa Receptor ◽

Benzodiazepine Binding

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Homology modeling in tandem with 3D-QSAR analyses: A computational approach to depict the agonist binding site of the human CB2 receptor

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.07.023 ◽

2011 ◽

Vol 46 (9) ◽

pp. 4489-4505 ◽

Cited By ~ 28

Author(s):

Elena Cichero ◽

Alessia Ligresti ◽

Marco Allarà ◽

Vincenzo di Marzo ◽

Zelda Lazzati ◽

...

Keyword(s):

Homology Modeling ◽

Binding Site ◽

3D Qsar ◽

Computational Approach ◽

Agonist Binding ◽

Cb2 Receptor

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Cellulase enzyme: Homology modeling, binding site identification and molecular docking

Journal of Molecular Structure ◽

10.1016/j.molstruc.2017.08.067 ◽

2017 ◽

Vol 1150 ◽

pp. 61-67 ◽

Cited By ~ 9

Author(s):

K. Selvam ◽

D. Senbagam ◽

T. Selvankumar ◽

C. Sudhakar ◽

S. Kamala-Kannan ◽

...

Keyword(s):

Molecular Docking ◽

Homology Modeling ◽

Binding Site ◽

Cellulase Enzyme ◽

Binding Site Identification ◽

Site Identification

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A Transmembrane Binding Site at a Subunit Interface for Torpedo Nicotinic Acetylcholine Receptor Potentiators And Inhibitors

Biophysical Journal ◽

10.1016/j.bpj.2009.12.708 ◽

2010 ◽

Vol 98 (3) ◽

pp. 131a

Author(s):

Ayman K. Hamouda ◽

Deidre Stewart ◽

S. Shaukat Husain ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface ◽

A Subunit

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Homology Modeling of a Human Glycine Alpha 1 Receptor Reveals a Plausible Anesthetic Binding Site.

ChemInform ◽

10.1002/chin.200516210 ◽

2005 ◽

Vol 36 (16) ◽

Author(s):

Edward J. Bertaccini ◽

Jessica Shapiro ◽

Douglas L. Brutlag ◽

James R. Trudell

Keyword(s):

Homology Modeling ◽

Binding Site

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Identification of amino acid residues responsible for the α5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABAA receptor

Journal of Neurochemistry ◽

10.1046/j.1471-4159.2001.00289.x ◽

2001 ◽

Vol 77 (2) ◽

pp. 445-451 ◽

Cited By ~ 44

Author(s):

M. Anna Casula ◽

Frances A. Bromidge ◽

Gopalan V. Pillai ◽

Peter B. Wingrove ◽

Karine Martin ◽

...

Keyword(s):

Amino Acid ◽

Binding Site ◽

Gabaa Receptor ◽

Amino Acid Residues ◽

Binding Selectivity ◽

Benzodiazepine Binding

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Homology modeling and binding site assessment of the human P-glycoprotein

Future Medicinal Chemistry ◽

10.4155/fmc.10.276 ◽

2011 ◽

Vol 3 (3) ◽

pp. 297-307 ◽

Cited By ~ 14

Author(s):

Ákos Tarcsay ◽

György M Keserű

Keyword(s):

Homology Modeling ◽

Binding Site ◽

Site Assessment ◽

P Glycoprotein

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