A Study of the Rationale of the Treatment of Delirium Tremens with Adrenocorticotropic Hormone; II. Clinical Correlations to Responsiveness to ACTH in Delirium Tremens

1954 ◽  
Vol 15 (3) ◽  
pp. 387-401 ◽  
Author(s):  
Margaret Owen
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Delirium Tremens ◽  
Clinical Correlations

Adrenocorticotropin Production by a Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 462-463
Author(s):  
K.S. McCarty ◽  
N.R. Wallace ◽  
W. Litaker ◽  
S. Wells ◽  
G. Eisenbarth
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Small Cell ◽  
Hormone Production ◽  
Carcinoma Of The Breast ◽  
Ectopic Acth ◽  
Ultrastructural Studies ◽  
Subcutaneous Metastases ◽  
Ectopic Acth Production ◽  
The Right ◽  
Pituitary Carcinomas

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.

Morphometric SEM study of the effects of ACTH on endothelial fenestrae in the rat adrenal cortex

1984 ◽  
Vol 42 ◽  
pp. 234-235
Author(s):  
J. Curtis ◽  
K. S. Schwartz ◽  
R. P. Apkarian
Keyword(s):  
Anterior Pituitary ◽  
Lipid Droplets ◽  
Adrenocorticotropic Hormone ◽  
Unit Area ◽  
High Density Lipoproteins ◽  
Capillary Endothelium ◽  
Zona Fasciculata ◽  
Sem Study ◽  
Saline Vehicle ◽  
Scanning Electron

A scanning electron microscope (SEM) study was made of the effect of adrenocorticotropic hormone (ACTH) on the size and numbers of fenestrae/unit area in the capillary endothelium of the zona fasciculata (ZF) of the rat adrenal. The stimulatory effect of ACTH on cholesterol uptake via high density lipoproteins in the rat and evidence for the secretion of glucocorticoids by exocytosis of lipid droplets described by Rhodin suggest that endothelial change may accompany these transport phenomena.Twelve rats received two Dexamethasone (DEX) ip injections (25 μg DEX/100 g body wt.), the first at 8 PM and the second at 8 AM the next day, to inhibit the release of endogenous ACTH by the anterior pituitary. The animals were then divided into two groups. Six animals received only saline vehicle and six rats received ACTH (100 ng/100 g body wt.).

Das Alkoholentzugssyndrom: Delirium tremens und Krampfanfall

2010 ◽  
Vol 56 (2) ◽  
pp. 95-105 ◽  
Author(s):  
Ulrich C. Lutz ◽  
Anil Batra
Keyword(s):  
Delirium Tremens ◽  
Genetische Faktoren

Ziel: Gravierendste, lebensbedrohliche Komplikationen des Alkoholentzugssyndroms sind Entzugskrampfanfall und Delirium tremens. Die Übersichtsarbeit stellt die typische Symptomatik, sich aus der Anamnese ergebende Risikofaktoren, ätiologisch relevante neurobiologische Faktoren sowie den Versuch der Identifikation von Biomarkern inklusive genetischer Polymorphismen für das Delirium tremens und den Alkoholentzugskrampfanfall vor. Methodik: Es erfolgte eine systematische Literaturrecherche mit Hilfe der Datenbank Pubmed unter Auswahl aktueller Studien und Übersichtsarbeiten zu dem Thema. Ergebnisse: Aktuelle neurobiologische Modelle favorisieren eine gesteigerte glutamaterge und reduzierte GABAerge Transmission als Grundlage für eine zerebrale Hyperexzitabilität. Als Risikofaktoren für die Entstehung eines Delirium tremens und eines Entzugskrampfanfalls wurden serologische und genetische Faktoren identifiziert. Bei den genetischen Faktoren handelt es sich um Polymorphismen innerhalb von Kandidatengenen insbesondere im dopaminergen und glutamatergen Transmittersystem. Schlussfolgerungen: Neue Befunde aus dem Bereich der Neurobiologie erlauben Einblicke in die Ätiopathogenese des Alkoholentzugssyndroms und tragen zum Verständnis des Alkoholentzugskrampfanfalls und des Delirium tremens bei.

The Treatment of Delirium Tremens

1956 ◽  
Vol 17 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Leo H. Berman
Keyword(s):  
Delirium Tremens
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