EARLY EFFECTS OF GLUCOCORTICOIDS ON RIBONUCLEIC ACID AND PROTEIN METABOLISM IN RAT LIVER

1963 ◽  
Vol 44 (4_Suppla) ◽  
pp. S3-S36 ◽  
Author(s):  
Kristian F. Jervell
Keyword(s):  
Rat Liver ◽  
Ribonucleic Acid ◽  
Protein Metabolism ◽  
Early Effects

scholarly journals A comparative study of the early effects of phenobarbital and 3-methylcholanthrene on the synthesis and transport of ribonucleic acid in rat liver

1980 ◽  
Vol 186 (1) ◽  
pp. 81-87 ◽  
Author(s):  
A Kumar ◽  
M R S Rao ◽  
G Padmanaban
Keyword(s):  
Comparative Study ◽  
Rat Liver ◽  
Ribonucleic Acid ◽  
Rna Synthesis ◽  
Transcriptional Response ◽  
Primary Effect ◽  
Transient Phenomenon ◽  
Time Points ◽  
Early Effects ◽  
Nucleolar Rna

At 2-3 h after phenobaribtal administration, the drug has no effect on nucleoplasmic RNA synthesis and decreases nucleolar RNA synthesis. However, at this time there is an increase in the labelling of cytoplasmic poly(A)-containing RNA, even though there is decreased labelling of total polyribosomal RNA. The decrease in labelling of nucleolar and total polyribosomal RNA owing to phenobarbital is a transient phenomenon. Under similar conditions, 3-methylcholanthrene has no effect on nucleolar RNA synthesis, but leads to an increase in synthesis of nucleoplasmic and cytoplasmic poly(A)-containing RNA. Cytosol isolated from phenobarbital-treated, but not from 3-methyl-cholanthrene-treated, animals facilitates an enhanced transport of RNA from nuclei. At the time points investigated, 3-methylcholanthrene or its metabolite shows a 10-15-fold higher concentration in the chromatin than that of phenobarbital or its metabolite. It is suggested that the primary effect of phenobarbital is at the cytoplasmic level, promoting the transport of RNA from the nuclei, which can act as a trigger for enhanced transcription at later periods. 3-Methylcholanthrene or its metabolite directly binds to the chromatin and evokes a selective transcriptional response.

Early effects of cortisone on nucleic acid and protein metabolism of rat liver

1962 ◽  
Vol 55 (4) ◽  
pp. 495-504 ◽  
Author(s):  
Muriel Feigelson ◽  
Paul R. Gross ◽  
Philip Feigelson
Keyword(s):  
Nucleic Acid ◽  
Rat Liver ◽  
Protein Metabolism ◽  
Early Effects

scholarly journals Studies on the Nuclear and Nucleolar Ribonucleic Acid of Regenerating Rat Liver

1965 ◽  
Vol 240 (10) ◽  
pp. 3960-3966
Author(s):  
Masami Muramatsu ◽  
Harris Busch
Keyword(s):  
Rat Liver ◽  
Ribonucleic Acid ◽  
Regenerating Rat Liver

5S Ribonucleic acid-protein complex extracted from rat liver ribosomes by formamide

Biochemistry ◽  
1972 ◽  
Vol 11 (12) ◽  
pp. 2323-2326 ◽  
Author(s):  
Mary L. Petermann ◽  
Mary G. Hamilton ◽  
Amalia Pavlovec
Keyword(s):  
Rat Liver ◽  
Protein Complex ◽  
Ribonucleic Acid ◽  
Acid Protein ◽  
Liver Ribosomes
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