QUANTITATIVE RELATIONS IN THE AQUEOUS FLARE RESPONSE INDUCED BY α-MELANOCYTE STIMULATING HORMONE IN THE RABBIT EYES

1965 ◽  
Vol 49 (1) ◽  
pp. 166-176 ◽  
Author(s):  
K. Dyster-Aas ◽  
C. E. T. Krakau
Keyword(s):  
Subcutaneous Injection ◽  
Great Variability ◽  
Local Administration ◽  
Aqueous Flare ◽  
Melanocyte Stimulating Hormone ◽  
Flare Response ◽  
Stimulating Hormone

ABSTRACT The aqueous flare response (AFR) to MSH is induced in an increasing percentage of animals with increasing age. The great variability of the responses and the fact that local administration of MSH is not more efficient with lower doses than by subcutaneous injection indicate that the AFR is a complex result in which general factors play a part. The analysis of the variation of the responses has led to a procedure for testing the effect of different preparations.

EFFECTS OF THE MELANOCYTE STIMULATING HORMONE AND OF AN INDUCED SERUM FACTOR ON EYE PERMEABILITY AND SERUM LEVEL OF FREE FATTY ACIDS IN THE RABBIT

1968 ◽  
Vol 59 (3) ◽  
pp. 487-496 ◽  
Author(s):  
H. K. Dyster-Aas ◽  
C. E. T. Krakau
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Serum Level ◽  
Ciliary Body ◽  
Rabbit Serum ◽  
Serum Factor ◽  
Melanocyte Stimulating Hormone ◽  
Flare Response ◽  
Stimulating Hormone

ABSTRACT A subcutaneous injection of melanocyte stimulating hormone (MSH) in the rabbit may give an aqueous flare response (permeability disturbance in the ciliary body) and serum from such a rabbit may induce a similar effect in another rabbit. Serum from this rabbit may in the next rabbit induce the same effect. The permeability effect obtained by serum injection is not accompanied by a free fatty acid (FFA) release, in contrast to the MSH effect. The FFA are not a prerequisite for a flare effect, though they may play a role in the production of the serum factor. The serum factor can hardly be a MSH compound.

GENERAL EFFECTS OF α-MELANOCYTE STIMULATING HORMONE IN THE RABBIT

1965 ◽  
Vol 48 (4) ◽  
pp. 609-618 ◽  
Author(s):  
H. K. Dyster-Aas ◽  
C. E. T. Krakau
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Systemic Effects ◽  
List Type ◽  
Aqueous Flare ◽  
Melanocyte Stimulating Hormone ◽  
Blood Aqueous Barrier

ABSTRACT In addition to the previously described permeability disturbance in the blood aqueous barrier of the eye, measured as an increase of the aqueous flare, a series of transitory systemic effects have been recorded following the subcutaneous injection of synthetic α-MSH: marked increase of the free fatty acids in plasma, decrease in the serum calcium level, decrease in the blood pressure, increase in the skin temperature, increased frequency and diminished amplitude of respiration, presence of slow waves in the EEG. There is a correlation between the magnitude of the aqueous flare increase and the increase of free fatty acids in plasma and also between the aqueous flare and the minimum serum calcium level.

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