Assessment of quality of life of patients with Cushing's syndrome depending on the disease course

2017 ◽  
Author(s):  
Gulchekhra Narimova ◽  
Zamira Yusupovna ◽  
Ravshan Fayzullaev ◽  
Iskandar Arifjanov
Keyword(s):  
Quality Of Life ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Disease Course

Adrenalectomy may improve cardiovascular and metabolic impairment and ameliorate quality of life in patients with adrenal incidentalomas and subclinical Cushing's syndrome

Surgery ◽  
2012 ◽  
Vol 152 (6) ◽  
pp. 991-997 ◽  
Author(s):  
Maurizio Iacobone ◽  
Marilisa Citton ◽  
Giovanni Viel ◽  
Riccardo Boetto ◽  
Italo Bonadio ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Adrenal Incidentalomas ◽  
Subclinical Cushing’S Syndrome

scholarly journals Small cerebellar cortex volume in patients with active Cushing's syndrome

2014 ◽  
Vol 171 (4) ◽  
pp. 461-469 ◽  
Author(s):  
Alicia Santos ◽  
Eugenia Resmini ◽  
Iris Crespo ◽  
Patricia Pires ◽  
Yolanda Vives-Gilabert ◽  
...  
Keyword(s):  
Quality Of Life ◽  
White Matter ◽  
Cerebellar Cortex ◽  
Cushing’S Syndrome ◽  
Visual Memory ◽  
Cushing's Syndrome ◽  
Life Assessment ◽  
Age At Diagnosis ◽  
Cerebellar Volume

ObjectiveCushing's syndrome (CS) is associated with neuropsychological deficits. As the cerebellum plays a key role in neuropsychological functions it may be affected in CS. The aim of this study was to investigate whether patients with CS have a smaller cerebellar volume than healthy controls, and to analyse whether cerebellar volume is associated with neuropsychological performance and clinical parameters.DesignA cross-sectional study was performed.MethodsThirty-six CS patients (15 with active CS and 21 with CS in remission) and 36 controls matched for age, sex, and education underwent neuropsychological testing, quality of life assessment, clinical evaluation, and magnetic resonance imaging brain scan. Cerebellar volumes (white matter and cortex, bilateral) were calculated using FreeSurfer Software.ResultsPatients with active CS showed smaller bilateral cerebellar cortex volumes than controls (left,P=0.035 and right,P=0.034), as well as a trend toward smaller right cerebellar cortex volumes than patients in remission CS (P=0.051). No differences were observed in the volume of cerebellar white matter between the three groups. Both right and left cerebellar cortex volumes correlated negatively with triglyceride levels (right:r=−0.358,P=0.002 and left:r=−0.317,P=0.005) and age at diagnosis (right:r=−0.433,P=0.008 and left:r=−0.457,P=0.005). Left cerebellar cortex volume also correlated positively with visual memory performance (r=0.245,P=0.038). Right cerebellar cortex volume positively correlated with quality-of-life scores (r=0.468,P=0.004).ConclusionsThe cerebellar cortex volume is smaller in active CS patients than in controls. This finding is associated with poor visual memory and quality of life and is mostly pronounced in patients with higher triglyceride levels and older age at diagnosis.

scholarly journals Psychopathology, memory and quality of life in Cushing's syndrome

2016 ◽  
Author(s):  
Alicia Santos ◽  
Eugenia Resmini ◽  
Iris Crespo ◽  
Elena Valassi ◽  
Maria Antonia Martinez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome

scholarly journals Improvement but no normalization of quality of life and cognitive functioning after treatment for Cushing’s syndrome

2019 ◽  
Author(s):  
Leonie H A Broersen ◽  
Cornelie D Andela ◽  
Olaf M Dekkers ◽  
Alberto M Pereira ◽  
Nienke R Biermasz
Keyword(s):  
Quality Of Life ◽  
Cognitive Functioning ◽  
Cushing’S Syndrome ◽  
Meta Analysis ◽  
Cushing's Syndrome ◽  
Treatment Quality ◽  
Cross Sectional ◽  
Effective Interventions ◽  
Before And After

Abstract Background Cushing’s syndrome is characterized by glucocorticoid excess, which induces physical and mental symptoms, impairments in functional status and perceived health, resulting in impaired quality of life. Biochemical remission is urgently required; however, quality of life and cognitive function may remain impaired. Objective To perform a systematic review and meta-analysis evaluating changes in health-related quality of life and cognitive functioning in patients with Cushing’s syndrome after treatment. Methods Eight electronic databases were searched in March 2017, and PubMed again in May 2018, to identify potentially relevant articles. Eligible studies were (randomized controlled) trials, cohort studies, and cross-sectional studies assessing quality of life or cognitive functioning in patients treated for Cushing’s syndrome. Differences were expressed as standardized mean difference, and reported with 95% confidence intervals. We compared patients before and after treatment (improvement), and patients after treatment and healthy controls (normalization). Results We included 47 articles with 2,643 patients. Most patients had Cushing’s disease and were in remission after treatment. Quality of life and cognitive functioning improved after treatment in all studied domains. Compared to a healthy control population, quality of life did not normalize. Cognitive functioning normalized in part, but not all, of the studied domains. Conclusions Treatment of Cushing’s syndrome improves quality of life and cognitive functioning. As normalization was not achieved in quality of life and in some aspects of cognitive functioning, special and continuous attention should be given to these aspects for patients after treatment. Effective interventions for further improvement and possibly normalization are urgently needed.

scholarly journals Development and evaluation of a health‐related quality‐of‐life tool for dogs with Cushing's syndrome

2019 ◽  
Vol 33 (6) ◽  
pp. 2595-2604 ◽  
Author(s):  
Imogen Schofield ◽  
Dan G. O'Neill ◽  
Dave C. Brodbelt ◽  
David B. Church ◽  
Rebecca F. Geddes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Health Related Quality ◽  
Life Tool ◽  
Related Quality ◽  
Health Related

scholarly journals Long-Term Impaired Quality of Life in Cushing’s Syndrome despite Initial Improvement after Surgical Remission

2006 ◽  
Vol 91 (2) ◽  
pp. 447-453 ◽  
Author(s):  
John R. Lindsay ◽  
Tonya Nansel ◽  
Smita Baid ◽  
Julie Gumowski ◽  
Lynnette K. Nieman
Keyword(s):  
Quality Of Life ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Initial Improvement ◽  
Impaired Quality
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