The proinflammatory molecule, VAP-1, is enriched in the stroma of midgut NETs and plaques of carcinoid heart disease valves

2018 ◽  
Author(s):  
Vandana M Sagar ◽  
Desley AH Neil ◽  
Pantelitsa Papakyriacou ◽  
Tahir Shah ◽  
Boyang Liu ◽  
...  
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease ◽  
Proinflammatory Molecule

scholarly journals Carcinoid Heart Disease

1974 ◽  
Vol 67 (5) ◽  
pp. 321-322
Author(s):  
S H Dave ◽  
E C B Keat
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

Carcinoid Heart Disease: a Review

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Faidon-Marios Laskaratos ◽  
Joseph Davar ◽  
Christos Toumpanakis
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

scholarly journals Flow-driven right-to-left cardiac shunting in a patient with carcinoid heart disease and patent foramen ovale without elevated right atrial pressure: a case report and literature review

2020 ◽  
Author(s):  
Parinita Dherange ◽  
Nelson Telles ◽  
Kalgi Modi
Keyword(s):  
Heart Disease ◽  
Patent Foramen Ovale ◽  
Atrial Septum ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Heart Catheterization ◽  
Carcinoid Heart Disease ◽  
Foramen Ovale ◽  
Arterial Blood

Abstract Background Carcinoid heart disease is present in approximately 20% of the patients with carcinoid syndrome and is associated with poor prognosis. It usually manifests with right-sided valvular involvement including tricuspid insufficiency and pulmonary stenosis. Patent foramen ovale (PFO) is present in approximately 50% of the patients with carcinoid heart disease which is twice higher than the general population. Right-to-left shunting through a PFO can occur either due to higher right atrial pressure than left (pressure-driven) or when the venous flow is directed towards the PFO (flow-driven) in the setting of normal intracardiac pressures. We report a rare case of flow-driven right-to-left atrial shunting via PFO in a patient with carcinoid heart disease. Case summary A 54-year-old male with a metastatic neuroendocrine tumour to liver presented with progressive shortness of breath for 5 months. Patient was found to be hypoxic with oxygen saturation of 78% and examination revealed a holosystolic murmur. Arterial blood gas showed oxygen tension of 43 mmHg. A transthoracic and transoesophageal echocardiogram showed aneurysmal inter-atrial septum with a PFO, severe tricuspid regurgitation directed anteriorly towards the inter-atrial septum leading to a marked right-to-left shunt. Right heart catheterization showed right atrial pressure of 8 mmHg, mean pulmonary artery pressure of 12 mmHg, and normal oxygen saturations in the right atrium, right ventricle, and pulmonary arteries. The patient then underwent closure of the PFO along with tricuspid valve and pulmonary valve replacement at an experienced cardiovascular surgical centre and has been asymptomatic since. Conclusion Right-to-left shunting through a PFO in patients with normal right atrial pressure can be successfully treated with closure of the PFO. Thus, understanding the mechanism of intracardiac shunts is important to accurately diagnose and treat this rare and fatal condition.

Current Concepts in Diagnosis and Perioperative Management of Carcinoid Heart Disease

2012 ◽  
Vol 17 (3) ◽  
pp. 212-223 ◽  
Author(s):  
Javier G. Castillo ◽  
George Silvay ◽  
Jorge Solís
Keyword(s):  
Heart Disease ◽  
Perioperative Management ◽  
Carcinoid Heart Disease

scholarly journals Carcinoid heart disease

2014 ◽  
Vol 33 (1) ◽  
pp. 59-60
Author(s):  
Ingrid do Rosário ◽  
Maria João Andrade ◽  
Isabel Arroja ◽  
Ana Plácido ◽  
Miguel Mendes
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

scholarly journals Echocardiographic spectrum of carcinoid heart disease

1991 ◽  
Vol 17 (2) ◽  
pp. A49
Author(s):  
Patricia A. Pellikka ◽  
Bijoy K. Khandheria ◽  
John A. Callahan ◽  
James B. Seward ◽  
A.Jamil Tajik
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

Transcatheter pulmonary valve implantation in carcinoid heart disease

2021 ◽  
Author(s):  
Michele Flagiello ◽  
Matteo Pozzi ◽  
Laurent Francois ◽  
Ahmed Al Harthy ◽  
Julien Forestier ◽  
...  
Keyword(s):  
Heart Disease ◽  
Pulmonary Valve ◽  
Carcinoid Heart Disease ◽  
Valve Implantation ◽  
Pulmonary Valve Implantation
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