scholarly journals Differential hormonal regulation of estrogen receptors ERα and ERβ and androgen receptor expression in rat efferent ductules

Reproduction ◽  
2004 ◽  
Vol 128 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Cleida A Oliveira ◽  
Germán A B Mahecha ◽  
Kay Carnes ◽  
Gail S Prins ◽  
Philippa T K Saunders ◽  
...  

Estrogen receptors, in addition to the androgen receptor (AR), are expressed at high levels in efferent ductules of the male reproductive tract and it is now well recognized that estrogen receptor (ER) α is required for the maintenance of normal structure and function of the ductules. However, little is known regarding the hormonal regulation of the receptors themselves in the male. In the present study, efferent ductule ligation and castration, followed by replacement with testosterone, dihydro-testosterone (DHT) or estradiol was used to investigate the relative importance of circulating and luminal sources of steroid for the modulation of ERα, ERβ and AR in rat efferent ductules. Uni- or bilateral castration and ligation did not affect the expression of ERα and ERβ, but bilateral castration caused down-regulation of AR. Replacement with DHT and testosterone alone or in combination with estradiol caused the recovery of AR expression to control levels. A slight recovery of AR was also observed after estrogen replacement. ERα expression was decreased to nearly undetectable levels after estrogen replacement. On the other hand, ERβ did not show evident effects following any of the treatments, suggesting a constitutive expression of this receptor. This differential modulation of the steroid hormone receptors highlights the importance of maintaining a physiological androgen-estrogen balance to regulate the structure and function of efferent ductules in the male.

Endocrinology ◽  
1982 ◽  
Vol 111 (1) ◽  
pp. 260-268 ◽  
Author(s):  
UH HEE KIM ◽  
THOMAS R. VAN OOSBREE ◽  
GERALD C. MUELLER

1998 ◽  
Vol 66 (5-6) ◽  
pp. 319-326 ◽  
Author(s):  
Marie Blanchere ◽  
Isabelle Berthaut ◽  
Marie-claire Portois ◽  
Chidi Mestayer ◽  
Irène Mowszowicz

1991 ◽  
Vol 626 (1 Frontiers in) ◽  
pp. 81-91 ◽  
Author(s):  
OLLI A. JÄNNE ◽  
LI-XIN SHAN

2018 ◽  
Vol 2018 ◽  
pp. 1-19 ◽  
Author(s):  
Namya Mellouk ◽  
Christelle Ramé ◽  
Alix Barbe ◽  
Jérémy Grandhaye ◽  
Pascal Froment ◽  
...  

Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species.


2011 ◽  
Vol 32 (3) ◽  
pp. 338-344 ◽  
Author(s):  
Xiao-ling Wang ◽  
Feng Kong ◽  
Tao Shen ◽  
Charles YF Young ◽  
Hong-xiang Lou ◽  
...  

1989 ◽  
Vol 17 (2) ◽  
pp. 87-93 ◽  
Author(s):  
A. O. Brinkmann ◽  
P. Klaasen ◽  
G. G. J. M. Kuiper ◽  
J. A. G. M. van der Korput ◽  
J. Bolt ◽  
...  

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