Rehabilitation strategies and results in patients treated with chemoradiotherapy/radiotherapy for head and neck cancer: Institutional  experience

Oncologic treatments, such as Radio- therapy and Chemo-radiation, for head and neck cancer can cause long-term swallowing impairments (dysphagia) that negatively impact the Quality of life. Radiation-induced dysphagia consists of a broad spectrum of structural, mechanical, and neurologic deficits. The goal of this study is to understand the importance of Onco Rehabilitation during Radiation and Chemo-Radiation to minimize the incidence of Dysphagia during the Treatment, which ultimately causes delay in Overall Treatment Time (OTT).

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Faculty Opinions recommendation of Late complications and long-term quality of life for survivors (>5 years) with history of head and neck cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717952796.793457670 ◽

2012 ◽

Author(s):

Giulio Cantu ◽

Madia Pompilio ◽

Paolo Formillo

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Late Complications ◽

History Of

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Long-term Single Institutional Experience with the Use of Daily Image-guided Radiotherapy (IGRT) for the Treatment of Head and Neck Cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2009.07.1506 ◽

2009 ◽

Vol 75 (3) ◽

pp. S660

Author(s):

S. Won ◽

J. Marsano ◽

B. Li ◽

R. Sreeraman ◽

A. Michaud ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Image Guided Radiotherapy ◽

Image Guided ◽

Institutional Experience

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Quality of Life of Patients with Head and Neck Cancer Receiving Cetuximab, Fluorouracil, Cisplatin Comparing to Cetuximab, Fluorouracil, Cisplatin and Docetaxel within the CEFCID Trial

Oncology Research and Treatment ◽

10.1159/000521415 ◽

2021 ◽

Author(s):

Ute Goerling ◽

Thomas Gauler ◽

Andreas Dietz ◽

Viktor Grünwald ◽

Stephan Knipping ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Treatment Time ◽

Life Questionnaire ◽

European Organization ◽

Global Quality Of Life ◽

The Impact

Introduction: CeFCiD was a multicenter phase II study comparing the efficacy of cetuximab, 5-flourouracil, cisplatin with the same regimen adding docetaxel in recurrent/metastatic head and neck cancer. The primary analysis trial did not demonstrate survival benefit from therapy intensification in first-line recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). The current analysis of the trial assessed the impact of treatment on quality of life (QoL). Methods: The European Organization for Research and Treatment of Cancer Quality of life Questionnaire QLQ-C30 and the tumor specific module for head and neck cancer (QLQ-H&N35) were used to assess QoL at baseline (visit 1), after 2 (visit 3), 4 (visit 5), and 6 (visit 7) cycles of chemotherapy. Results: Of 180 patients included in this study, 86 patients (47.8%) completed the questionnaires at baseline. Considering selected scores over treatment time, there was no difference in global quality of life, dyspnea, swallowing and speech between the treatment arms in the course. For fatigue a significant increase from baseline to visit 3 (p=0.02), visit 5 (p=0.002), and to visit 7 (p=0.003) was observed for patients receiving docetaxel (D), cisplatin or carboplatin (P), 5-FU (F) and cetuximab (C). At the end of chemotherapy the manifestation of fatigue was similar compared in the two treatment arms. Discussion/Conclusion: Therapy intensification not adversely affect selected scores of QoL of patients with recurrent and/or metastatic SCCHN. Nevertheless, fatigue seems to be pronounced in patients treated with docetaxel.

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