Congenital Cardiovascular Defects in Infants With Down Syndrome
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Editor's note: In response to a reader's question about cardiac evaluation of patients with Down syndrome, we asked Dr Clark for a review and recommendation for workup by the general pediatrician. RJH Infants with Down syndrome are at 50% risk for congenital cardiovascular malformations1 compared with a 0.3% (3 of 1000) risk for infants with normal chromosomes.2 These data confirm the original estimates of Rowe and Uchida3; other estimates have ranged from 20% to 70%. The types of heart defects found in persons with Down syndrome are severe: complete atrioventricular canal, ventricular septal defect, partial atrioventricular canal, atrial septal defect, tetralogy of Fallot, and patent ductus arteriosus.4
2021 ◽
Vol 13
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pp. 292
2014 ◽
Vol 30
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pp. 46-49
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2014 ◽
Vol 3
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pp. 15621-15624
2009 ◽
Vol 134
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pp. e82-e83
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