scholarly journals Systemic corticosteroid in the treatment of a 9-year-old boy with Oral Mucous Membrane Pemphigoid: A case report

2017 ◽  
Vol 31 (4) ◽  
pp. 186
Author(s):  
Brunno Santos de Freitas Silva ◽  
Jorge Elias Kaluf Tomeh ◽  
Claudeir Felipe De Oliveira Siqueira ◽  
Simone Sousa Silva Sant'Ana ◽  
Fernanda Paula Yamamoto-Silva
Keyword(s):  
Mucous Membrane ◽  
Systemic Corticosteroid ◽  
Mucous Membrane Pemphigoid ◽  
Low Doses ◽  
Oral Mucous Membrane ◽  
Systemic Corticosteroids ◽  
Attached Gingiva ◽  
Burning Mouth Sensation ◽  
Systemic Corticosteroid Therapy

AIM: This report is present a rare case of oral Mucous Membrane Pemphigoid (MMP) in a 9-yearold- boy successfully treated with low doses of systemic corticosteroid.CASE DESCRIPTION: A 9-year-old boy was referred to our service with the complaint of painful gingiva and generalized burning mouth sensation over 1 year. Intraoral examination revealed desquamative lesions affecting the entire attached gingiva of both the maxilla and the mandible. After the incisional biopsy the MMP diagnosis was confirmed, and the patient was initially treated with dexamethasone 0,1 mg/Ml mouth rinse twice daily for 24 weeks. Due the difficulty in eating and the presence of persistent large oral lesions, systemic prednisone 20 mg (1 mg/kg) was prescribed for 4 weeks with a 5 mg gradual reduction per week over 3 weeks. After initiating the systemic corticosteroid therapy, the patient showed total regression of the lesions, and no indication of recurrence has been observed in the past 6 months.CONCLUSION: There is no cure for MMP; however, treatment can provide complete and longlasting remission. Based on this premise, it is plausible to consider not only topical but also low doses of systemic corticosteroids in resistant cases of oral MMP, even in children. These measures could improve the quality of life of these patients by reducing pain and, consequently, improving the child’s eating behavior.

Stressful Life Events as a Trigger for Autoimmune Disease? A Case Report on Mucous Membrane Pemphigoid

Dental Update ◽  
2021 ◽  
Vol 48 (5) ◽  
pp. 379-382
Author(s):  
Robert Devine ◽  
Melanie Simms
Keyword(s):  
Mucous Membrane ◽  
Patient Outcomes ◽  
Stressful Life Events ◽  
Treatment Options ◽  
Rare Condition ◽  
Corticosteroid Treatment ◽  
Diagnostic Tools ◽  
Mucous Membrane Pemphigoid ◽  
Acute Presentation

This case discusses the acute presentation of a patient with mucous membrane pemphigoid to an emergency dental department. Mucous membrane pemphigoid is a rare condition, but its presentation can be severe and concerning for both the patient and clinician. The case presents the manifestations of florid desquamative gingivitis and extensive mucosal erosions due to burst bullae. We discuss the possible causes of the condition in this patient, likely to be the stress of recent cardiac surgery, as well as exploring the efficacy of diagnostic tools, treatment options and adverse effects of corticosteroid treatment. CPD/Clinical Relevance: Correct and timely diagnosis of vesiculobullous disorders has notable impacts on patient outcomes and quality of life.

scholarly journals Childhood Oral Mucous Membrane Pemphigoid Presenting as Desquamative Gingivitis in a 4-year-old Girl

2006 ◽  
Vol 86 (4) ◽  
pp. 351-354 ◽  
Author(s):  
SV Lourenço ◽  
P Boggio ◽  
LE Martins ◽  
CG Santi ◽  
V Aoki ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Mucous Membrane Pemphigoid ◽  
Oral Mucous Membrane

scholarly journals P.162 Effects of Systemic Corticosteroid Treatment on Pseudotumoral Hemicerebellitis

2021 ◽  
Vol 48 (s3) ◽  
pp. S66-S66
Author(s):  
A Vivekanandan ◽  
B Santyr ◽  
A Ranger
Keyword(s):  
Systemic Corticosteroid ◽  
Pediatric Population ◽  
Corticosteroid Treatment ◽  
Mass Effect ◽  
Cerebellar Dysfunction ◽  
Systemic Corticosteroids ◽  
The Mean ◽  
Mean Time ◽  
Post Infectious ◽  
Systemic Corticosteroid Therapy

Background: Pseudotumoral hemicerebellitis is an acute, unilateral inflammation of the cerebellum that typically affects the pediatric population. The etiology remains to be elucidated, however frequently is attributed to post-infectious inflammation. Though it tends to be self-resolving, treatment may reduce the time to symptomatic recovery. Systemic corticosteroid therapy has been proposed as a mechanism for improving outcomes and time to symptomatic recovery. Methods: We present a case report of a 12-year-old male with pseudotumoral hemicerebellitis and unilateral cerebellar dysfunction. Additionally, we briefly review the additional 35 reported cases of pseudotumoural hemicerebellitis with respect to length of time to symptomatic recovery with or without systemic corticosteroid treatment. Results: 30 cases reported length of time to symptomatic recovery. Including our case, the mean time to recovery for those treated with systemic corticosteroids (n=20) was 48.05 days(SE=16.3). The mean time to recovery for those treated without (n=10) was 86.7 days(SE=29.3). Conclusions: Treatment with systemic corticosteroids was associated with a faster time to symptomatic recovery compared to without. Regardless of etiology, reducing inflammation and mass effect involved in pseudotumoral hemicerebellitis may be integral to a more rapid return to neurological baseline.

A case of oral mucous membrane pemphigoid with IgG antibodies to integrin α6β4

2014 ◽  
Vol 171 (6) ◽  
pp. 1555-1557 ◽  
Author(s):  
S. Miyamoto ◽  
D. Chikazu ◽  
T. Yasuda ◽  
A. Enomoto ◽  
T. Oh-i ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Mucous Membrane Pemphigoid ◽  
Igg Antibodies ◽  
Oral Mucous Membrane ◽  
Integrin Α6β4

scholarly journals Unilateral Oral Mucous Membrane Pemphigoid: Refractory Atypical Presentation Successfully Treated with Intravenous Immunoglobulins

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
André Laureano ◽  
Jorge Cardoso
Keyword(s):  
Mucous Membrane ◽  
Intravenous Immunoglobulins ◽  
Mucous Membrane Pemphigoid ◽  
Direct Immunofluorescence ◽  
Oral Mucous Membrane ◽  
Mucosal Involvement ◽  
Oral Corticosteroids ◽  
Local Trauma ◽  
Palate Mucosa ◽  
The Right

A 57-year-old male presented with a 6-month history of blisters and painful erosions on the right buccal mucosa. No skin or other mucosal involvement was seen. The findings of histopathological and direct immunofluorescence examinations were sufficient for the diagnosis of oral mucous membrane pemphigoid in the context of adequate clinical correlation. No response was seen after topical therapies and oral corticosteroids or dapsone. Intravenous immunoglobulin was started and repeated every three weeks. Complete remission was achieved after three cycles and no recurrence was seen after two years of follow-up. The authors report a rare unilateral presentation of oral mucous membrane pemphigoid on the right buccal and hard palate mucosa, without additional involvement during a period of five years. Local trauma or autoimmune factors are possible etiologic factors for this rare disorder, here with unique presentation.

Sign in / Sign up

Export Citation Format

Share Document