Data are presented on the outcome of 43 pregnancies between 1983 and 1991. Maintenance of pregnancy
in agonadal women begins at the time of embryo implantation, and initial hormone replacement therapy
to prime the endometrium before embryo transfer is an important factor. Synchronization in agonadal
women is successful with the variable-length oestrogen replacement regime but can be difficult in
ovulating recipients.
The outcome of donor egg (DE) pregnancies in this study is comparable to that of IVF pregnancies,
with the possible exception of an increased rate of monozygous twins. Pre-eclampsia does not appear
to increase significantly in DE pregnancies. Vaginal delivery is possible for DE pregnancies in women
with ovarian failure.
Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer
