QUANTITATIVE MORPHO-FUNCTIONAL ANALYSIS OF SIMMETRY-ASIMMETRY CONDITION OF HUMAN NORMAL KIDNEY

2020 ◽  
Vol 23 (1) ◽  
pp. 1-6
Author(s):  
M. Dgebuadze ◽  
G. Svanidze ◽  
D. Gachechiladze

The aim of the present research was to perform quantitative morpho-functional analysis of the symmetry-asymmetry condition of human normal autopsy and “live” kidneys using the complex of morphological and ultra-sonographic methods. METHODS: Morphometric study of 10 autopsy kidneys of healthy men 36 - 60 years of age was conducted; retrospective analysis of data obtained by vital ultra-sonographic study of 65 kidneys of men without renal diseases at the same age period was performed as well. All kidneys were with a single renal artery. RESULTS: The kidney length and width are statistically significantly greater on right, than on left, but there were no statistically significant differences between right and left kidneys in thickness of the kidney and size of its parenchyma. Results of morphometric study of autopsy renal glomeruli, as well as multislice computed tomographic angiography and doppler investigation of renal artery in color duplex scan mode did not show any statistically significant differences on right and on left. CONCLUSIONS: For determining of the standard quantitative indicators of kidney it is necessary to take into account the age and gender of the studied people, as well as the effect of side.

2004 ◽  
Vol 141 (9) ◽  
pp. 674 ◽  
Author(s):  
G. Boudewijn C. Vasbinder ◽  
Patricia J. Nelemans ◽  
Alfons G.H. Kessels ◽  
Abraham A. Kroon ◽  
Jeffrey H. Maki ◽  
...  

2020 ◽  
Vol 6 (2) ◽  
pp. 26-34
Author(s):  
Răzvan-Andrei Licu ◽  
Emanuel Blîndu ◽  
Diana Opincariu ◽  
Theodora Benedek

AbstractBackground: All plaques that trigger acute coronary syndromes (ACS) present various characteristics of vulnerability. However, not all vulnerable plaques (VP) lead to an ACS. This raises the question as to which of the established CT vulnerability features hold the highest probability of developing ACS.Aim: To identify the distinct phenotype of VP that exposes the unstable atheromatous plaque to a higher risk of rupture.Material and Methods: In total, 20 patients in whom cardiac computed tomographic angiography (CCTA) identified the presence of a vulnerable plaque and who developed an ACS within 6 months after CCTA examination were enrolled in the study, and compared to 20 age- and gender-matched subjects with VPs who did not develop an ACS. All included patients presented VPs at baseline, defined as the presence of minimum 50% degree of stenosis and at least one CT marker of vulnerability (low attenuation plaques [LAP], napkin-ring sign [NRS], positive remodeling [PR], spotty calcifications [SCs]).Results: The two groups were not different in regards to age, gender, cardiovascular risk factors, and comorbidities. Patients who developed an ACS at six months presented higher volumes of lipid-rich (p = 0.01) and calcified plaques (p = 0.01), while subjects in the control group presented plaques with a larger fibrotic content (p = 0.0005). The most frequent vulnerability markers within VPs that had triggered ACS were LAPs (p <0.0001) and PR (p <0.0001). Multivariate analysis identified LAP as the strongest independent predictor of ACS at 6 months in our study population (OR 8.18 [1.23-95.08], p = 0.04).Conclusions: VPs producing an ACS exhibit a different phenotype compared to VPs that remain silent. The CCTA profile of VPs producing an ACS includes the presence of low attenuation, positive remodeling, and lipid-rich atheroma. The presence of these features in VPs identifies very high-risk patients, who can benefit from adapted therapeutic strategies in order to prevent an ACS.


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