Alternative treatment approaches in epilepsy: Mini-review

2011 ◽  
Vol 5 (4) ◽  
pp. 189-197
Author(s):  
Muhammad Liaquat Raza
2015 ◽  
Vol 42 (5) ◽  
pp. 1083-1085 ◽  
Author(s):  
Berenice Royal

2021 ◽  
pp. 106002802110220
Author(s):  
Madeline G. Tompkins ◽  
Rebecca Pettit

Objective: To review the available literature addressing alternative allergic bronchopulmonary aspergillosis (ABPA) treatment options for patients with cystic fibrosis (CF). Data Sources: A literature search of PubMed was performed (January 2002 to April 2021) using the following search terms: allergic bronchopulmonary aspergillosis, aspergillus-related lung disease, cystic fibrosis. Manufacturer prescribing information, clinical practice guidelines, and data from ClinicalTrials.gov were incorporated in the reviewed data. Study Selection and Data Extraction: Relevant English-language studies or those conducted in humans were considered for inclusion. Data Synthesis: Available literature for alternative ABPA treatments in CF is lacking randomized controlled trials, but there is considerable support in case reports and case series describing the benefits in pediatric and adult patients. Recent literature has begun to explore the place in therapy for novel, corticosteroid-sparing treatment approaches. The alternative therapies summarized in this review all resulted in clinical improvement and subsequent discontinuation or dose reductions of oral corticosteroids, with minimal reported adverse drug effects. Relevance to Patient Care and Clinical Practice: Although corticosteroids are the cornerstone of ABPA management, the toxicities can be significant limitations in an already high-risk patient population. Patients may fail or become intolerant to guideline-recommended therapies and require alternative treatment approaches. Conclusions: Alternative treatment modalities for ABPA in patients with CF, including azole antifungals, pulsed intravenous glucocorticoids, omalizumab, mepolizumab, and inhaled amphotericin, appear to be efficacious and well tolerated. Pharmacological properties including route of administration, storage and stability, beyond use dating, and adverse effects of the various treatment modalities must be considered when selecting a practical care plan for patients.


1986 ◽  
Vol 5 (2) ◽  
pp. 9-15 ◽  
Author(s):  
P. Susan Penfold ◽  
Gillian A. Walker

While purporting to be benign, compassionate, and helpful, psychiatry functions as a social regulator. Its unrecognized inter-relationship with the social system allows psychiatry to participate in women's oppression, locating the problem within the individual woman and obscuring the invidious effects of social structures. Psychiatric theories can reflect and reinforce longstanding beliefs about women's status and role, contribute to her devalued status, blame her for her difficulties, minimize violence against her, and suggest that her behaviour should be shaped so that she can conform to the traditional role. A feminist perspective provides a different view and alternative treatment approaches.


1988 ◽  
Vol 152 (1) ◽  
pp. 134-136 ◽  
Author(s):  
Michael Sharpe ◽  
Bernice Andrew

A case is reported of a severely depressed patient in whom treatment with electroconvulsive therapy was abandoned because of repeated failure to induce a convulsion. Reasons for the failure to convulse and alternative treatment approaches are discussed.


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